CAJ | 학술논문

目的评价生长抑素、垂体后叶素及奥美拉唑三联治疗肝硬化食管胃底静脉曲张破裂出血的疗效和不良反应.方法将157例肝硬化并食管胃底静脉曲张破裂出血患者随机分为三组:生长抑素、垂体后叶素及奥美拉唑三联(A)组77例,单用生长抑素(B)组42例及单用垂体后叶素(C)组38例,记录并比较三组药物治疗上消化道出血的疗效及不良反应.结果 A组治疗食管胃底静脉曲张破裂出血有效率93%(72/77),明显高于B组78%(33/42)和C组55%(21/38),P均＜0.05.A组药物不良反应发生率为22%,明显低于C组(44%,P＜0.05),而与B组差异无统计学意义(14%,P＞0.05).结论生长抑素、垂体后叶素及奥美拉唑三联治疗肝硬化食管胃底静脉曲张破裂出血安全、有效.
목적 평개생장억소、수체후협소급오미랍서삼련치료간경화식관위저정맥곡장파렬출혈적료효화불량반응.방법 장157례간경화병식관위저정맥곡장파렬출혈환자수궤분위삼조:생장억소、수체후협소급오미랍서삼련(A)조77례,단용생장억소(B)조42례급단용수체후협소(C)조38례,기록병비교삼조약물치료상소화도출혈적료효급불량반응.결과 A조치료식관위저정맥곡장파렬출혈유효솔93%(72/77),명현고우B조78%(33/42)화C조55%(21/38),P균＜0.05.A조약물불량반응발생솔위22%,명현저우C조(44%,P＜0.05),이여B조차이무통계학의의(14%,P＞0.05).결론 생장억소、수체후협소급오미랍서삼련치료간경화식관위저정맥곡장파렬출혈안전、유효.
Objective To investigate the clinical effects and adverse events of somatostatin, pituitrin and omeprazole in the patients with esophageal and gastric variceal bleeding and liver cirrhosis. Methods 157 patients with esophageal and gastric variceal bleeding and liver cirrhosis were divided into three groups:group A(77cases), group B(42 cases)and group C(38 cases).Group A received somatostatin, pituitrin and omeprazole. Group B were treated with somatostatin while Group C were treated with pituitrin. The clinical effects and adverse events of patients were recorded and investigated. Results The effective rate of group A was significantly higher than that of group B(93% vs 78%, P＜0.05) and that of group C(93% vs 55%, P＜0.05). The rate of adverse events of group A was significantly lower than that of group C(22% vs 44%, P＜0.05). There were no statistical differences in the rate of adverse events between group A and group B (22% vs 14%, P＞0.05). Conclusion Somatostatin, pituitrin and omeprazole is an effective and safe drug for esophageal and gastric variceal bleeding in liver cirrhosis patients.