CAJ | 학술논문

我们用轻度烧伤动物模型研究了烧伤后红细胞（RBC）变形性及渗透脆性的变化。结果发现，轻度烧伤后红细胞变形性随时间有一先抑后扬的变化趋势。烧伤后立即取血（0h）所测结果与烧伤前比较，RBC最大变形指数(DI)max、积分变形指数IDI及红细胞渗透脆性都未见显著性差异；烧伤后1、2h时(DI)max、IDI显著降低（P<0.01或P<0.05）；4、7 h时( DI)max、IDI虽略低于烧伤前水平，但未见显著性差异（P>0.05）。烧伤后不同时间点（0、1、2 、4、7h）所取血样的RBC渗透脆性与烧伤前比较，除在烧伤后4h时显著增加外，在其余各时间点均未见显著变化。说明在用该动物模型所得结果中，(DI)max、IDI的受损及RBC渗透脆性的增加，可能都只与体液因素的作用有关。但RBC变形性的受损与其渗透脆性的变化不是同步的，说明可能存在着不同的损伤机制。
아문용경도소상동물모형연구료소상후홍세 포（RBC）변형성급삼투취성적변화。결과발현，경도소상후홍세포변형성수시간유일선억 후양적변화추세。소상후립즉취혈（0h）소 측결과여소상전비교，RBC최대변형지수(DI)max、적분변형지수IDI급홍세포삼투취성도미 견현저성차이；소상후1、2h시(DI)max、IDI현저강저（P<0.01혹P<0.05）；4、7 h시( DI)max、IDI수략저우소상전수평，단미견현저성차이（P>0.05）。소상후불동시간점 （0、1、2 、4、7h）소취혈양적RBC삼투취성여소상전비교，제재소상후4h시현저증가외，재기여각시 간점균미견현저변화。설명재용해동물모형소득결과중，(DI)max、IDI적수손급RBC삼투취 성적증가，가능도지여체액인소적작용유관。단RBC변형성적수손여기삼투취성적변화불시 동보적，설명가능존재착불동적손상궤제。
The changes in erythrocyte deformability and os moti c fragility were studied with an animal model of mild burn injury. The results s howed that after the burn injury there was a gradual decrease with time at first and then a recovery in erythrocyte deformability. Maximum deformation index ［(DI)max］, integra tion deformation index (IDI) and osmotic fragility of RBCs drawn just after burn were almost identical to those before burn injury. (DI)max and IDI signifi cantly decreased at 1, 2 h but not at 4, 7 h when compared with those before burn injury, however, the RBCs were less deformable at 4, 7 h. Erythrocyte osmotic fragility significantly increased only at 4 h after burn injury when compared at the time points of 0, 1, 2, 4 , 7 h after burn with that before burn injury. The results indicated that the lesion in (DI)max and IDI, and the increase in osmotic fragility might be only related to the body fluid fa ctors in this animal model. The decrease in erythrocyte deformability and the in crease in erythrocyte osmotic fragility did not synchronize, suggesting that the changes might come about not by the same mechanism.