CAJ | 학술논문

目的提高对遗传性非息肉病性大肠癌（HNPCC）本质的认识，了解其家庭易感性及聚集倾向。方法对5例HNPCC家系进行回顾性分析。结果HNPCC的主要特点是常染色体显性遗传，病灶好发于右半结肠，伴发大肠以外器官恶性肿瘤，发病年龄轻。结论应对HNPCC患者及其家族严密监测、随访，以便早期诊断，合理治疗，改善预后。
목적제고대유전성비식육병성대장암（HNPCC）본질적인식，료해기가정역감성급취집경향。방법대5례HNPCC가계진행회고성분석。결과HNPCC적주요특점시상염색체현성유전，병조호발우우반결장，반발대장이외기관악성종류，발병년령경。결론응대HNPCC환자급기가족엄밀감측、수방，이편조기진단，합리치료，개선예후。
Objective To understand the hereditary susceptibility and theoccurrence pattern of hereditary nonpolyposis colorectal cancer (HNPCC) in members of the families with a clear family history. Methods A retrospective analysis of 5 families with history of HNPCC was conducted. Results HNPCC occured at relatively young ages(mean 46.5 years) with a increased tendency of proximal colon cancer in the family members under investigation, often complicated by extrocolorected malignancy. Conclusions Close attention should be paid to the family members of the patients with HNPCC and regular follow-up performed to detect the malignancy as early as possible to improve the prognosis of potential patients.