化学与生物工程
化學與生物工程
화학여생물공정
CHEMISTRY & BIOENGINEERING
2009年
7期
29-31
,共3页
水杨酸正戊酯%硫酸氢钠%催化%合成
水楊痠正戊酯%硫痠氫鈉%催化%閤成
수양산정무지%류산경납%최화%합성
n-amyl salicylate%sodium hydrogen sulfate%catalysis%synthesis
以水杨酸和正戊醇为原料,用一水合硫酸氢钠催化合成水杨酸正戊酯.研究了酸醇摩尔比、催化剂用量、反应时间及带水剂用量等因素对酯收率的影响.结果表明,一水合硫酸氢钠是合成水杨酸正戊酯的良好催化剂.最佳反应条件如下:酸醇摩尔比为1∶1.5,催化剂用量为反应物总质量的4.7%,带水剂环己烷用量为10 mL,反应时间为4.5 h,反应温度为120～140℃.在此条件下,水杨酸正戊酯的收率可达93.3%.
以水楊痠和正戊醇為原料,用一水閤硫痠氫鈉催化閤成水楊痠正戊酯.研究瞭痠醇摩爾比、催化劑用量、反應時間及帶水劑用量等因素對酯收率的影響.結果錶明,一水閤硫痠氫鈉是閤成水楊痠正戊酯的良好催化劑.最佳反應條件如下:痠醇摩爾比為1∶1.5,催化劑用量為反應物總質量的4.7%,帶水劑環己烷用量為10 mL,反應時間為4.5 h,反應溫度為120～140℃.在此條件下,水楊痠正戊酯的收率可達93.3%.
이수양산화정무순위원료,용일수합류산경납최화합성수양산정무지.연구료산순마이비、최화제용량、반응시간급대수제용량등인소대지수솔적영향.결과표명,일수합류산경납시합성수양산정무지적량호최화제.최가반응조건여하:산순마이비위1∶1.5,최화제용량위반응물총질량적4.7%,대수제배기완용량위10 mL,반응시간위4.5 h,반응온도위120～140℃.재차조건하,수양산정무지적수솔가체93.3%.
n-Amyl salicylate was synthesized from salicylic acid and n-pentanol using sodium hydrogen sulfate as catalyst. Factors influencing the ether yield,such as molar ratio of alcohol to acid,catalyst dosage,reaction time,water carrier dosage were discussed. Experimental results showed that sodium hydrogen sulfate was an excellent catalyst. The optimum synthetic conditions were as follows: molar ratio of salicylic acid to n-pentanol was 1∶1.5,catalyst dosage was 4.7% of mass of the reactants,using 10 mL of cyclohexane as water carrier,reaction temperature was 120～140℃ and reaction time was 4.5 h.Under above conditions, the yield of n-amyl salicylate achieved 93.3%.
