中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
16期
4-7
,共4页
陈秋%韩文群%梁永碧%张勤%黎瑶%左志煌%孙丽莎
陳鞦%韓文群%樑永碧%張勤%黎瑤%左誌煌%孫麗莎
진추%한문군%량영벽%장근%려요%좌지황%손려사
胰岛素%糖尿病,2型%血糖
胰島素%糖尿病,2型%血糖
이도소%당뇨병,2형%혈당
Insulin%Diabete smellitus,type2%Blood glucose
目的 探讨甘精胰岛素控制2型糖尿病患者血糖的有效性和安全性,验证新的2型糖尿病治疗方案“一个中心、三步曲”.方法 采用多中心的随机、开放性、自身对照研究,对入选的203例2型糖尿病患者给予甘精胰岛素治疗,分为一针方案、一针一药方案、一长多短方案、一长一药多短方案四组,分别为30、106、48、19例,观察患者治疗前后血糖、糖化血红蛋白(HbA1c)、体重等变化.结果 治疗前患者的空腹血糖(FPG)(11.73±4.49) mmol/L,餐后2h血糖(2hPPG)( 16.73±4.96) mmol/L,HbA1c(9.43±2.31)％,治疗后分别为(5.78±0.76) mmol/L、(8.37±1.37) mmol/L、(6.81±0.38)％,均较治疗前显著降低(P＜0.01).治疗前后体重和体质指数比较差异无统计学意义(P＞0.05).四组患者治疗后FPG、2hPPG、HbA1c均较治疗前显著下降,差异有统计学意义(P＜0.01).治疗过程中仅1例患者出现低血糖反应.结论 “—个中心、三步曲”治疗方案,是一种既有效、安全,又方便、经济的2型糖尿病的治疗方案.
目的 探討甘精胰島素控製2型糖尿病患者血糖的有效性和安全性,驗證新的2型糖尿病治療方案“一箇中心、三步麯”.方法 採用多中心的隨機、開放性、自身對照研究,對入選的203例2型糖尿病患者給予甘精胰島素治療,分為一針方案、一針一藥方案、一長多短方案、一長一藥多短方案四組,分彆為30、106、48、19例,觀察患者治療前後血糖、糖化血紅蛋白(HbA1c)、體重等變化.結果 治療前患者的空腹血糖(FPG)(11.73±4.49) mmol/L,餐後2h血糖(2hPPG)( 16.73±4.96) mmol/L,HbA1c(9.43±2.31)％,治療後分彆為(5.78±0.76) mmol/L、(8.37±1.37) mmol/L、(6.81±0.38)％,均較治療前顯著降低(P＜0.01).治療前後體重和體質指數比較差異無統計學意義(P＞0.05).四組患者治療後FPG、2hPPG、HbA1c均較治療前顯著下降,差異有統計學意義(P＜0.01).治療過程中僅1例患者齣現低血糖反應.結論 “—箇中心、三步麯”治療方案,是一種既有效、安全,又方便、經濟的2型糖尿病的治療方案.
목적 탐토감정이도소공제2형당뇨병환자혈당적유효성화안전성,험증신적2형당뇨병치료방안“일개중심、삼보곡”.방법 채용다중심적수궤、개방성、자신대조연구,대입선적203례2형당뇨병환자급여감정이도소치료,분위일침방안、일침일약방안、일장다단방안、일장일약다단방안사조,분별위30、106、48、19례,관찰환자치료전후혈당、당화혈홍단백(HbA1c)、체중등변화.결과 치료전환자적공복혈당(FPG)(11.73±4.49) mmol/L,찬후2h혈당(2hPPG)( 16.73±4.96) mmol/L,HbA1c(9.43±2.31)％,치료후분별위(5.78±0.76) mmol/L、(8.37±1.37) mmol/L、(6.81±0.38)％,균교치료전현저강저(P＜0.01).치료전후체중화체질지수비교차이무통계학의의(P＞0.05).사조환자치료후FPG、2hPPG、HbA1c균교치료전현저하강,차이유통계학의의(P＜0.01).치료과정중부1례환자출현저혈당반응.결론 “—개중심、삼보곡”치료방안,시일충기유효、안전,우방편、경제적2형당뇨병적치료방안.
Objective To investigate the effectiveness and safety of insulin glargine in the treatment of patients with type 2 diabetes mellitus (T2DM),and verify the new remedy called "one central and three steps" for T2DM.Methods Used multicenter,random,open and self-control study.Two hundred and three cases with T2DM treated with insulin glargine were divided into four groups according to different therapy:30 cases with one needle method,106 cases with one needle and one pill method,48 cases with one long-acting and several short-acting method,and 19 cases with one long-acting,one pill and several short-acting method.The changes of blood glucose,glycosylated hemoglobin (HbA1c),weight and so on before and after treatment were observed.Results The levels of fasting plasma glucose (FPG),2 h postprandial plasma glucose (2hPPG) and HbA1c decreased significantly after treatment than those before treatment [(5.78 ±0.76)mmol/L,(8.37 ±:1.37) mmol/L,(6.81 ±0.38)％ vs. (11.73 ±4.49) mmol/L,(16.73 ±4.96) mmol/L,(9.43 ± 2.31 )％,P ＜ 0.01 ].The weight and body mass index had no obvious changes before and after treatment( P ＞ 0.05 ).There was significant difference in the level of FPG,2hPPG and HbA1c before and after treatment in four groups respectively(P＜0.01 ).There was only 1 case who occurred hypoglycemia during the treatment.Conclusion The therapy,"one central and three steps",is not only effective and safe,but also convenient and cheap for T2DM.
