中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
7期
17-19
,共3页
氨氯地平%高血压%心脏扩大%贝那普利
氨氯地平%高血壓%心髒擴大%貝那普利
안록지평%고혈압%심장확대%패나보리
Amlodipine%Hypertension%Cardiomegaly%Benazepril
目的 观察苯磺酸左旋氨氯地平联合贝那普利治疗原发性高血压并左室肥厚的临床疗效.方法 将98例原发性高血压并左室肥厚患者按随机数字表法分为两组,每组49例,观察组采用苯磺酸左旋氨氯地平联合贝那普利治疗,对照组仅采用苯磺酸左旋氨氯地平治疗,比较两组的临床疗效及收缩压、舒张压、左室后壁厚度(LVPW)、左室舒张末期室间隔厚度(IVST)、左室舒张末期内径(LVEDD)、左室质量指数(LVMI)的差异.结果 观察组总有效率为93.9％(46/49),显著高于对照组的77.6％( 38/49),差异有统计学意义(x2=5.333,P＜0.05).两组治疗前收缩压及舒张压水平比较差异无统计学意义(P＞0.05).治疗后两组收缩压及舒张压均较治疗前显著下降(P＜0.05)；并且观察组治疗后收缩压及舒张压水平显著低于同期对照组[(121.27±8.69) mm Hg(1 mm Hg=0.133kPa)比(131.54±9.85) mm Hg,(82.45±4.69) mm Hg比(88.49±5.14) mm Hg](P＜ 0.05).两组治疗前LVPW、IVST、LVEDD及LVMI水平比较差异无统计学意义(P＞0.05),治疗后两组LVPW、IVST、LVEDD及LVMI均明显下降(P＜0.05),并且观察组治疗后LVPW、IVST、LVEDD及LVMI明显低于同期对照组[(9.42±1.58) mm比(11.41±1.92) mm,(9.56±1.31) mm比(11.38±1.85) mm,(47.86±2.38) mm比(51.46±3.25) mm,(108.16±6.24) g/m2比(119.21±7.68) g/m2](P＜ 0.05).结论 苯磺酸左旋氨氯地平联合贝那普利对原发性高血压并左室肥厚患者进行治疗,能够明显降低血压,改善患者左室肥厚状态,值得临床推广应用.
目的 觀察苯磺痠左鏇氨氯地平聯閤貝那普利治療原髮性高血壓併左室肥厚的臨床療效.方法 將98例原髮性高血壓併左室肥厚患者按隨機數字錶法分為兩組,每組49例,觀察組採用苯磺痠左鏇氨氯地平聯閤貝那普利治療,對照組僅採用苯磺痠左鏇氨氯地平治療,比較兩組的臨床療效及收縮壓、舒張壓、左室後壁厚度(LVPW)、左室舒張末期室間隔厚度(IVST)、左室舒張末期內徑(LVEDD)、左室質量指數(LVMI)的差異.結果 觀察組總有效率為93.9％(46/49),顯著高于對照組的77.6％( 38/49),差異有統計學意義(x2=5.333,P＜0.05).兩組治療前收縮壓及舒張壓水平比較差異無統計學意義(P＞0.05).治療後兩組收縮壓及舒張壓均較治療前顯著下降(P＜0.05)；併且觀察組治療後收縮壓及舒張壓水平顯著低于同期對照組[(121.27±8.69) mm Hg(1 mm Hg=0.133kPa)比(131.54±9.85) mm Hg,(82.45±4.69) mm Hg比(88.49±5.14) mm Hg](P＜ 0.05).兩組治療前LVPW、IVST、LVEDD及LVMI水平比較差異無統計學意義(P＞0.05),治療後兩組LVPW、IVST、LVEDD及LVMI均明顯下降(P＜0.05),併且觀察組治療後LVPW、IVST、LVEDD及LVMI明顯低于同期對照組[(9.42±1.58) mm比(11.41±1.92) mm,(9.56±1.31) mm比(11.38±1.85) mm,(47.86±2.38) mm比(51.46±3.25) mm,(108.16±6.24) g/m2比(119.21±7.68) g/m2](P＜ 0.05).結論 苯磺痠左鏇氨氯地平聯閤貝那普利對原髮性高血壓併左室肥厚患者進行治療,能夠明顯降低血壓,改善患者左室肥厚狀態,值得臨床推廣應用.
목적 관찰분광산좌선안록지평연합패나보리치료원발성고혈압병좌실비후적림상료효.방법 장98례원발성고혈압병좌실비후환자안수궤수자표법분위량조,매조49례,관찰조채용분광산좌선안록지평연합패나보리치료,대조조부채용분광산좌선안록지평치료,비교량조적림상료효급수축압、서장압、좌실후벽후도(LVPW)、좌실서장말기실간격후도(IVST)、좌실서장말기내경(LVEDD)、좌실질량지수(LVMI)적차이.결과 관찰조총유효솔위93.9％(46/49),현저고우대조조적77.6％( 38/49),차이유통계학의의(x2=5.333,P＜0.05).량조치료전수축압급서장압수평비교차이무통계학의의(P＞0.05).치료후량조수축압급서장압균교치료전현저하강(P＜0.05)；병차관찰조치료후수축압급서장압수평현저저우동기대조조[(121.27±8.69) mm Hg(1 mm Hg=0.133kPa)비(131.54±9.85) mm Hg,(82.45±4.69) mm Hg비(88.49±5.14) mm Hg](P＜ 0.05).량조치료전LVPW、IVST、LVEDD급LVMI수평비교차이무통계학의의(P＞0.05),치료후량조LVPW、IVST、LVEDD급LVMI균명현하강(P＜0.05),병차관찰조치료후LVPW、IVST、LVEDD급LVMI명현저우동기대조조[(9.42±1.58) mm비(11.41±1.92) mm,(9.56±1.31) mm비(11.38±1.85) mm,(47.86±2.38) mm비(51.46±3.25) mm,(108.16±6.24) g/m2비(119.21±7.68) g/m2](P＜ 0.05).결론 분광산좌선안록지평연합패나보리대원발성고혈압병좌실비후환자진행치료,능구명현강저혈압,개선환자좌실비후상태,치득림상추엄응용.
Objective To observe the effect of levamlodipine besylate combined with benazepril in treatment of primary hypertension with left ventricular hypertophy.Methods Ninety-eight primary hypertension with left ventricular hypertrophy patients were divided into two groups by random number table.Observation group(49 cases) was treated with levamlodipine besylate combined with benazepril,and control group (49 cases) was only treated with levamlodipine besylate.The clinical effect,the levels of systolic blood pressure (SBP),diastolic blood pressure (DBP),left ventricular posterior wall (LVPW),interventricular septal thickness (IVST),left ventricular end-diastolic dimension (LVEDD) and left ventricular mass index (LVMI) were compared between two groups.Results The total effective rate in observation group was 93.9％ ( 46/49 ),which was significantly higher than that in control group (77.6％,38/49 ) ( x2 =5.333,P ＜0.05).Before treatment,the differences were not statistically significant in the levels of SBP and DBP (P ＞0.05).After treatment,the levels of SBP,DBP,LVPW,IVST,LVEDD and LVMI were significantly decreased in both groups (P＜0.05).Moreover,the levels of SBP,DBP,LVPW,IVST,LVEDD and LVMI in observation group after treatment were significantly lower than those in control group[ ( 121.27 ± 8.69 ) mmHg( 1 mm Hg =0.133 kPa) vs.( 131.54 ± 9.85 ) mm Hg,( 82.45 ± 4.69 ) mm Hg vs.( 88.49 ± 5.14 ) mmHg,(9.42 ± 1.58 ) mm vs.( 11.41 ± 1.92 ) mm,(9.56 ± 1.31 )mm vs.( 11.38 ± 1.85 ) mm,(47.86 ± 2.38 ) mm vs.(51.46 ±3.25) mm,(108.16 ±6.24) g/m2 vs.(119.21 ±7.68) g/m2] (P ＜0.05).Conclusion Levamlodipine besylate combined with benazepril in treatment of primary hypertension with left ventricular hypertrophy can improve the clinical effects and ease left ventricular hypertrophy status,which can be applied in clinic.
