CAJ | 학술논문

钩端螺旋体病是一种世界范围内流行的人兽共患传染病,临床表现复杂多变,主要表现为肝肾肺的损伤.目前,在钩端螺旋体病的诊断和预防方面,都缺乏较好的候选抗原.与此同时,在基因水平研究钩端螺旋体的致病机制又存在一定的困难.蛋白质组学是从整体水平研究生物体蛋白质组成的一门学科.因此,钩端螺旋体的研究可以从其蛋白质组水平,借助蛋白质组的研究手段和方法去发掘新的诊断技术和疫苗候选抗原,以及阐明钩端螺旋体的致病机制.
구단라선체병시일충세계범위내류행적인수공환전염병,림상표현복잡다변,주요표현위간신폐적손상.목전,재구단라선체병적진단화예방방면,도결핍교호적후선항원.여차동시,재기인수평연구구단라선체적치병궤제우존재일정적곤난.단백질조학시종정체수평연구생물체단백질조성적일문학과.인차,구단라선체적연구가이종기단백질조수평,차조단백질조적연구수단화방법거발굴신적진단기술화역묘후선항원,이급천명구단라선체적치병궤제.
Leptospirosis is a worldwide zoonotic disease, and its clinical manifestations are complexity, which mainly shows the damage of liver, kidney and lung. Until now, limits antigens can be employed in diagnosis and prevention. Meanwhile, there are many troubles in getting the pathogenesis of Leptospira through genetic manuplation.Proteomics is one of the system biology which study the protein composition of organism. Therefore, employed methods of proteomics is a new way to get new antigens of diagnosis and vaccine, and acquire the pathogenic mechanisms of Leptospira .