CAJ | 학술논문

目的探讨外周血T细胞亚群及自然杀伤细胞(NK细胞)监测与恶性肿瘤复发或转移的关系.方法采用流式细胞术检测48例恶性肿瘤复发或转移患者(复发或转移组)及48例恶性肿瘤无复发或转移患者(对照组)外周血T细胞亚群及NK细胞,并进行比较.结果复发或转移组辅助性T细胞(Th)/抑制性T细胞(Ts)为0.95±0.52,较对照组的1.35±0.43下降,差异有统计学意义(P=0.000),CD4+/CD25+为7.15±3.81,较对照组的6.01±2.67升高,差异有统计学意义(P=0.040),NK细胞为0.2053±0.1135,较对照组的0.2501±0.0745下降,差异有统计学意义(P=0.001).结论对肿瘤患者定期监测外周血T细胞亚群及NK细胞,能及时反映机体免疫状况,早期发现恶性肿瘤复发或转移.该方法简便易行,适合临床应用,有助于治疗后随访.
목적 탐토외주혈T세포아군급자연살상세포(NK세포)감측여악성종류복발혹전이적관계.방법 채용류식세포술검측48례악성종류복발혹전이환자(복발혹전이조)급48례악성종류무복발혹전이환자(대조조)외주혈T세포아군급NK세포,병진행비교.결과 복발혹전이조보조성T세포(Th)/억제성T세포(Ts)위0.95±0.52,교대조조적1.35±0.43하강,차이유통계학의의(P=0.000),CD4+/CD25+위7.15±3.81,교대조조적6.01±2.67승고,차이유통계학의의(P=0.040),NK세포위0.2053±0.1135,교대조조적0.2501±0.0745하강,차이유통계학의의(P=0.001).결론 대종류환자정기감측외주혈T세포아군급NK세포,능급시반영궤체면역상황,조기발현악성종류복발혹전이.해방법간편역행,괄합림상응용,유조우치료후수방.
Objective To investigate the relationships between T and NK cells in peripheral blood and the relapse or metastasis of malignant tumors.Methods Flow cytometry was used to test the percentages ofT and NK cells in peripheral blood of 48 malignant tumor patients with relapse or metastasis (relapse or metastasis group) and 48 malignant tumor patients without relapse or metastasis (control group).Results Compared with control group,the ratio of Th/Ts decreased,CD4+/CD25+ raised and the activities of NK cells decreased in relapse or metastasis group (0.95 ±0.52 vs.1.35 ±0.43,7.15 ±3.81 vs.6.01 ±2.67,0.2053 ±0.1135 vs.0.2501 ±0.0745)(P＜0.01 or ＜0.05).Conclusions Testing the T and NK cells in peripheral blood of malignant tumor patients regularly can know their immune status and find the relapse or metastasis early.It is easy and useful in patients' follow-up.