中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2011年
2期
159-161
,共3页
序贯疗法%三联疗法%幽门螺杆菌%十二指肠溃疡
序貫療法%三聯療法%幽門螺桿菌%十二指腸潰瘍
서관요법%삼련요법%유문라간균%십이지장궤양
Sequential therapy%Triple therapy%Hp%Duodenal ulcer
目的 评价序贯疗法与标准三联疗法对幽门螺杆菌(Hp)阳性十二指肠溃疡的Hp根除和溃疡愈合情况.方法 将95例Hp阳性的十二指肠溃疡活动期患者随机分为2组.序贯治疗组(48例)给予雷贝拉唑10 mg,阿莫西林1 g,连续口服5 d后再给矛雷贝拉唑10 mg,克拉霉素500 mg和替硝唑400 mg,均每天两次,连用10 d.标准三联组(47例)给予雷贝拉唑10 mg,克拉霉素500 mg和替硝唑400mg,均每天两次,连用7 d.所有患者在根治Hp后继续用雷贝拉唑10 mg,每日1次口服,合计总疗程均为4周.停药4周后复查胃镜观察溃疡愈合情况并检测Hp.结果 序贯治疗组Hp根除率89.5%(43/48),标准三联组Hp根除率70.2%(33/47),Hp根除率比较2组差异有统计学意义(P＜0.05).序贯治疗组溃疡愈合率87.5%(42/48),标准三联组溃疡愈合率82.9%(39/47),溃疡愈合率比较2组差异无统计学意义(P＞0.05).结论 序贯治疗对Hp阳性十二指肠溃疡患者Hp根除率高于标准三联疗法,溃疡愈合率近似.
目的 評價序貫療法與標準三聯療法對幽門螺桿菌(Hp)暘性十二指腸潰瘍的Hp根除和潰瘍愈閤情況.方法 將95例Hp暘性的十二指腸潰瘍活動期患者隨機分為2組.序貫治療組(48例)給予雷貝拉唑10 mg,阿莫西林1 g,連續口服5 d後再給矛雷貝拉唑10 mg,剋拉黴素500 mg和替硝唑400 mg,均每天兩次,連用10 d.標準三聯組(47例)給予雷貝拉唑10 mg,剋拉黴素500 mg和替硝唑400mg,均每天兩次,連用7 d.所有患者在根治Hp後繼續用雷貝拉唑10 mg,每日1次口服,閤計總療程均為4週.停藥4週後複查胃鏡觀察潰瘍愈閤情況併檢測Hp.結果 序貫治療組Hp根除率89.5%(43/48),標準三聯組Hp根除率70.2%(33/47),Hp根除率比較2組差異有統計學意義(P＜0.05).序貫治療組潰瘍愈閤率87.5%(42/48),標準三聯組潰瘍愈閤率82.9%(39/47),潰瘍愈閤率比較2組差異無統計學意義(P＞0.05).結論 序貫治療對Hp暘性十二指腸潰瘍患者Hp根除率高于標準三聯療法,潰瘍愈閤率近似.
목적 평개서관요법여표준삼련요법대유문라간균(Hp)양성십이지장궤양적Hp근제화궤양유합정황.방법 장95례Hp양성적십이지장궤양활동기환자수궤분위2조.서관치료조(48례)급여뢰패랍서10 mg,아막서림1 g,련속구복5 d후재급모뢰패랍서10 mg,극랍매소500 mg화체초서400 mg,균매천량차,련용10 d.표준삼련조(47례)급여뢰패랍서10 mg,극랍매소500 mg화체초서400mg,균매천량차,련용7 d.소유환자재근치Hp후계속용뢰패랍서10 mg,매일1차구복,합계총료정균위4주.정약4주후복사위경관찰궤양유합정황병검측Hp.결과 서관치료조Hp근제솔89.5%(43/48),표준삼련조Hp근제솔70.2%(33/47),Hp근제솔비교2조차이유통계학의의(P＜0.05).서관치료조궤양유합솔87.5%(42/48),표준삼련조궤양유합솔82.9%(39/47),궤양유합솔비교2조차이무통계학의의(P＞0.05).결론 서관치료대Hp양성십이지장궤양환자Hp근제솔고우표준삼련요법,궤양유합솔근사.
Objective To compare the efficacy of 10-day sequential therapy (including rabeprazole amoxillin clarithromycin tinidazole) and 7-day traditional trigeminy therapy (including rabeprazole amoxillin and clarithromycin) in patients with duodenobulbar ulcer and Hp infection. Methods Ninty-five patients with duodenobulbar ulcer and Hp infection were enrolled into the study and divided into two groups randomly:sequential therapy group and traditional trigeminy therapy group. Patients in the first group received 10-day sequential medications:rabeprazole 10 mg plus amoxillin 1 g for the first 5 days,followed by rabeprazole 10 mg plus clarithromycin 500 mg and tinidazole 500 mg for another 5 days;while in the second group patients received the standard 7-day traditional triple medications:rabeprazole 10 mg plus clarithromycin 500 mg and tinidazole 400 mg. All drugs were given twice daily. All patients received rabeprazole 10 mg daily following the two types of therapys for another four weeks. Hp statuses were assessed by rapid urease test and 14C urea breath test at baseline and 4 weeks after completion of the treatment. Ulcer cicatrization was assessed by gastroscope. Results The eradication rate of Hp infection was significantly higher in sequential group than triple group (89.5%vs. 70. 2%, P ＜ 0. 05 ), but we found no statistically significant difference in the comparison of the ulcer cicatrization rate between sequential group and triple group ( 87.5% vs. 82. 9%, P ＞ 0. 05 ). Conclusion Sequential therapy had a better Hp eradication effect than standard triple therapy, but the eradication rate was very close between the two therapys.
