中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
24期
13-15
,共3页
依达拉奉%急性肺损伤%抗氧化酶%氧自由基
依達拉奉%急性肺損傷%抗氧化酶%氧自由基
의체랍봉%급성폐손상%항양화매%양자유기
Edaravone%Acute lung injury%Antioxidase%Oxygen free radical
目的 探讨依达拉奉注射液对严重胸外伤导致的急性肺损伤(ALI)的预防及治疗作用.方法 将40例ALI患者随机分为依达拉奉治疗组(A组,20例)和对照组(B组,20例).检测血清丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、谷光甘肽过氧化物酶(GSH -Px)含量来评定氧自由基水平及自由基清除系统活性.结果 与B组比较,A组血浆中MDA含量下降,SOD、GSH和GSH - Px活力升高(P＜0.05).结论 依达拉奉可以预防及治疗严重胸外伤引起的急性肺损伤.
目的 探討依達拉奉註射液對嚴重胸外傷導緻的急性肺損傷(ALI)的預防及治療作用.方法 將40例ALI患者隨機分為依達拉奉治療組(A組,20例)和對照組(B組,20例).檢測血清丙二醛(MDA)、超氧化物歧化酶(SOD)、穀胱甘肽(GSH)、穀光甘肽過氧化物酶(GSH -Px)含量來評定氧自由基水平及自由基清除繫統活性.結果 與B組比較,A組血漿中MDA含量下降,SOD、GSH和GSH - Px活力升高(P＜0.05).結論 依達拉奉可以預防及治療嚴重胸外傷引起的急性肺損傷.
목적 탐토의체랍봉주사액대엄중흉외상도치적급성폐손상(ALI)적예방급치료작용.방법 장40례ALI환자수궤분위의체랍봉치료조(A조,20례)화대조조(B조,20례).검측혈청병이철(MDA)、초양화물기화매(SOD)、곡광감태(GSH)、곡광감태과양화물매(GSH -Px)함량래평정양자유기수평급자유기청제계통활성.결과 여B조비교,A조혈장중MDA함량하강,SOD、GSH화GSH - Px활력승고(P＜0.05).결론 의체랍봉가이예방급치료엄중흉외상인기적급성폐손상.
Objective To study the preventive and therapeutic effects of edaravone on acute lung injury.Methods Forty patients admitted in our hospital between November 2007 and January 2009 were divided into group A (n =20,treated with edaravone) and group B (n =20,treated with conventional therapy).The plasma level of malonaldehyde ( MDA),superoxidedismutase ( SOD),glutathione (GSH) and glutathione peroxidase (GSH - Px) were measured.Results Compared with group B,MDA level decreased,SOD,GSH and GSH - Px increased significantly in group A (P ＜ 0.05).Conclusions Edaravone exerts preventive and therapeutic effects on serious chest trauma induced acute lung injury.
