CAJ | 학술논문

模式动物小鼠是复杂性状相关疾病遗传研究的重要资源.连锁不平衡(linkage disequilib-rium,LD)是群体基因组遗传的重要信息.如果群体LD程度高,相关连锁区段大,有助于用少量遗传位标来对目标基因进行初步定位;反之,如果群体LD程度低,相关连锁区段小,则利用高密度的遗传位标可以对目标基因进行精细定位.本文介绍了实验小鼠群体和野生小鼠群体相关的LD、与LD相关的部分遗传参数以及利用LD进行相关基因定位研究.并提示实验小鼠和野生小鼠各具优势,都是复杂性状基因定位的重要遗传资源.
모식동물소서시복잡성상상관질병유전연구적중요자원.련쇄불평형(linkage disequilib-rium,LD)시군체기인조유전적중요신식.여과군체LD정도고,상관련쇄구단대,유조우용소량유전위표래대목표기인진행초보정위;반지,여과군체LD정도저,상관련쇄구단소,칙이용고밀도적유전위표가이대목표기인진행정세정위.본문개소료실험소서군체화야생소서군체상관적LD、여LD상관적부분유전삼수이급이용LD진행상관기인정위연구.병제시실험소서화야생소서각구우세,도시복잡성상기인정위적중요유전자원.
Mouse models have been extensively used for identification of susceptibility genes to complex trait diseases. Linkage disequilibrium ( LD) has been of great interest in genetic researches because of its utility in association studies of complex traits. Generally, extensive linkage disequilibrium is beneficial to perform gene mapping with a few markers at the initial stage. On the contrary, however, less extensive linkage disequilibrium is critical to perform fine mapping. In this review we introduced linkage disequilibrium and the genetic characteristics of linkage disequilibrium in laboratory mice and wild mice, as well as linkage disequilibrium mapping in association studies for complex traits. Finally, we prospect that both laboratory mice and wild mice have their advantages, and will be important genetic resources for identifying genes in complex traits.