国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2010年
5期
484-486
,共3页
糖尿病合并妊娠%先天性心脏病%心内膜垫%神经嵴细胞
糖尿病閤併妊娠%先天性心髒病%心內膜墊%神經嵴細胞
당뇨병합병임신%선천성심장병%심내막점%신경척세포
Pregestational diabetes mellitus%Congenital heart defects%Endocardial cushion%Neural crest cell
糖尿病合并妊娠可引起胎儿心脏畸形,是先天性心脏病重要的非遗传性风险因素;但其发病机制尚不清楚.近来研究表明:高糖作为重要的致畸因子,可影响心内膜垫形成和神经嵴细胞发育;心脏氧化应激损伤、心肌细胞调亡增加、细胞外基质合成增多以及心脏发育相关基因表达改变是其重要致病机制.
糖尿病閤併妊娠可引起胎兒心髒畸形,是先天性心髒病重要的非遺傳性風險因素;但其髮病機製尚不清楚.近來研究錶明:高糖作為重要的緻畸因子,可影響心內膜墊形成和神經嵴細胞髮育;心髒氧化應激損傷、心肌細胞調亡增加、細胞外基質閤成增多以及心髒髮育相關基因錶達改變是其重要緻病機製.
당뇨병합병임신가인기태인심장기형,시선천성심장병중요적비유전성풍험인소;단기발병궤제상불청초.근래연구표명:고당작위중요적치기인자,가영향심내막점형성화신경척세포발육;심장양화응격손상、심기세포조망증가、세포외기질합성증다이급심장발육상관기인표체개변시기중요치병궤제.
Pregestational diabetes mellitus may cause fetal heart defects,and it is considered to be an important non-genetic risk factors for congenital heart defects. However, the pathogenesis is unclear. Recent studies have shown that hyperglycemia, which acts as a primary teratogen in pregestational diabetes mellitus, may affect the endocardial cushion formation and neural crest cell development. Cardiac oxidative stress damage, increased myocardial cell apoptosis,increased synthesis of extracellular matrix, as well as the alteration of heart development-related genes expression are important pathogenic mechanism. In this paper, we review the progress in the effect and the pathogenesis of pregestational diabetes mellitus on heart development.
