中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
4期
14-17
,共4页
步长脑心通%尼莫同%血管性认知功能障碍%认知功能
步長腦心通%尼莫同%血管性認知功能障礙%認知功能
보장뇌심통%니막동%혈관성인지공능장애%인지공능
Naoxintong capsules%Nimotop%Vascular cognitive impairment%Cognitive function
目的 观察步长脑心通治疗前后血管性认知功能障碍(VCI)患者认知功能水平、甘油三酯(TG)、胆固醇(Tc)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、超敏C-反应蛋白(hs-CRP)的变化.方法 选取60例VCI患者,分为治疗组30例,采用步长脑心通胶囊治疗,每次3粒,每日3次,口服,连续3个月；对照组(标准对照)30例,采用尼莫同片治疗,每次1片,每日3次,口服,连续3个月.采用简易精神状态检查量表(MMSE)和蒙特利尔认知评估量表(MoCA)作为VCI患者的临床筛查工具.所有入选的患者均随访观察其治疗前及治疗后1、2、3个月的MMSE、MoCA评分,并在上述四个时间点采集外周静脉血标本,检测TG、TC、HDL-C、LDL-C和hs-CRP测值.结果 步长脑心通组与尼莫同组治疗后MMSE、MoCA评分均有改善,两组治疗前后比较差异有统计学意义(P＜0.05),治疗3个月后组间比较差异无统计学意义(P＞0.05)；步长脑心通组治疗前后TG、TC、HDL-C、LDL-C及hs-CRP水平差异有统计学意义(P＜0.05),而尼莫同组治疗前后上述指标水平无明显变化(P＞0.05).结论 步长脑心通治疗血管性认知功能障碍有一定的疗效,其对认知功能的改善与尼莫同相比疗效相当,且有调节血脂、降低hs-CRP的作用,而尼莫同则不明显.
目的 觀察步長腦心通治療前後血管性認知功能障礙(VCI)患者認知功能水平、甘油三酯(TG)、膽固醇(Tc)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)、超敏C-反應蛋白(hs-CRP)的變化.方法 選取60例VCI患者,分為治療組30例,採用步長腦心通膠囊治療,每次3粒,每日3次,口服,連續3箇月；對照組(標準對照)30例,採用尼莫同片治療,每次1片,每日3次,口服,連續3箇月.採用簡易精神狀態檢查量錶(MMSE)和矇特利爾認知評估量錶(MoCA)作為VCI患者的臨床篩查工具.所有入選的患者均隨訪觀察其治療前及治療後1、2、3箇月的MMSE、MoCA評分,併在上述四箇時間點採集外週靜脈血標本,檢測TG、TC、HDL-C、LDL-C和hs-CRP測值.結果 步長腦心通組與尼莫同組治療後MMSE、MoCA評分均有改善,兩組治療前後比較差異有統計學意義(P＜0.05),治療3箇月後組間比較差異無統計學意義(P＞0.05)；步長腦心通組治療前後TG、TC、HDL-C、LDL-C及hs-CRP水平差異有統計學意義(P＜0.05),而尼莫同組治療前後上述指標水平無明顯變化(P＞0.05).結論 步長腦心通治療血管性認知功能障礙有一定的療效,其對認知功能的改善與尼莫同相比療效相噹,且有調節血脂、降低hs-CRP的作用,而尼莫同則不明顯.
목적 관찰보장뇌심통치료전후혈관성인지공능장애(VCI)환자인지공능수평、감유삼지(TG)、담고순(Tc)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)、초민C-반응단백(hs-CRP)적변화.방법 선취60례VCI환자,분위치료조30례,채용보장뇌심통효낭치료,매차3립,매일3차,구복,련속3개월；대조조(표준대조)30례,채용니막동편치료,매차1편,매일3차,구복,련속3개월.채용간역정신상태검사량표(MMSE)화몽특리이인지평고량표(MoCA)작위VCI환자적림상사사공구.소유입선적환자균수방관찰기치료전급치료후1、2、3개월적MMSE、MoCA평분,병재상술사개시간점채집외주정맥혈표본,검측TG、TC、HDL-C、LDL-C화hs-CRP측치.결과 보장뇌심통조여니막동조치료후MMSE、MoCA평분균유개선,량조치료전후비교차이유통계학의의(P＜0.05),치료3개월후조간비교차이무통계학의의(P＞0.05)；보장뇌심통조치료전후TG、TC、HDL-C、LDL-C급hs-CRP수평차이유통계학의의(P＜0.05),이니막동조치료전후상술지표수평무명현변화(P＞0.05).결론 보장뇌심통치료혈관성인지공능장애유일정적료효,기대인지공능적개선여니막동상비료효상당,차유조절혈지、강저hs-CRP적작용,이니막동칙불명현.
Objective To investigate the clinical effect of Naoxintong capsules in treating patients with vascular cognitive impairment(VCI).Methods Sixty patients with VCI were randomly divided into treatment group(30 cases)and control group(30 cases).The treatment group were treated with Naoxintong capsules(3 capsules,tid,for 3 months).The control group were treated with Nimotop tablets (1 pills,tid,for 3 months).Mini-Mental State Examination(MMSE),Montreal Cognitive Assessment (MoCA)were used for screening patients with VCI.All selected patients were followed up the MMSE,MoCA scores and the measured value of TG,TC,HDL-C,LDL-C and hs-CRP before treatment and 1 month later,2 months later,and 3 months after treatment.Their peripheral blood specimen were collected in the above-mentioned four time points.Results MMSE and MoCA scores were improved in both groups after treatment.There were significant differences before and after treatment in the two groups (P＜0.05).The time when MMSE and MoCA scores changed significantly was a little bit later in the treatment group than that in the control group,but there were no significant difference between the two groups after three months of treatment(P＞0.05).There were significant differences in the levels of TG,TC,HDL-C,LDL-C and hs-CRP before and after treatment in the treatment group(P＜0.05).But there were no significant differences in the levels of the above-mentioned serum lipid and hs-CRP in the control group before and after treatment(P＞0.05).Conclusions Naoxintong capsules have a certain effect in treating patients with vascular cognitive impairment.Its effect on improving the cognitive function is equal to Nimotop,and has effect of regulating blood tipids and reducing hs-CRP level,which Nimotop doesn't have.
