CAJ | 학술논문

目的:观察糖尿病大鼠下颌下腺内细胞间黏附分子-1(ICAM-1)及肿瘤坏死因子-α(TNF-α)表达变化.方法:链脲佐菌素复制SD雄性大鼠糖尿病动物模型,分别于4周、12周后测体质量和血糖,H-E染色观察下颌下腺形态学变化,免疫组织化学SABC技术,检测ICAM-1及TNF-α蛋白表达变化.结果:糖尿病组大鼠下颌下腺组织萎缩,间质纤维增生.与对照组比较糖尿病组大鼠下颌下腺导管上皮细胞ICAM-1和TNF-α表达均显著增加.结论:ICAM-1及TNF-α参与了糖尿病病理变化过程.
목적:관찰당뇨병대서하합하선내세포간점부분자-1(ICAM-1)급종류배사인자-α(TNF-α)표체변화.방법:련뇨좌균소복제SD웅성대서당뇨병동물모형,분별우4주、12주후측체질량화혈당,H-E염색관찰하합하선형태학변화,면역조직화학SABC기술,검측ICAM-1급TNF-α단백표체변화.결과:당뇨병조대서하합하선조직위축,간질섬유증생.여대조조비교당뇨병조대서하합하선도관상피세포ICAM-1화TNF-α표체균현저증가.결론:ICAM-1급TNF-α삼여료당뇨병병리변화과정.
Objective: To investigate the changes of ICAM-1 and TNF-α expression in the submandibular gland of diabetic rats. Methods: A Sprague-Dawley diabetic rats model was induced by injection of streptozotocin. After 4 and 12 weeks, the rats were sacrificed for assaying weight and blood sugar,and the submandibular glands were observed by H-E staining and immunohistochemistry methods. Results: In diabetic rats, the submandibular gland was atrophied and the significant proliferating interstitial fiber was obstrved. Compared with the control group, ICAM-1 and TNF-α immunopositive cells in submandibular gland showed a ascending tendency with the progression of the disease. Immunopositive cells were more significantly increased in diabetic rats. Conclusion: ICAM-1 and TNF-α expression has a certain regulation in the diabetic pathogensis.