国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2010年
1期
6-9
,共4页
微小RNA%靶基因%肿瘤%治疗
微小RNA%靶基因%腫瘤%治療
미소RNA%파기인%종류%치료
miRNA%Target gene%Neoplasms%Therapy
微小RNA(miRNA)是近年来发现的一类长度为19～25碱基的非编码小分子单链RNA,普遍存在于生物界,在不同物种间具有高度的保守性,其表达具有细胞特异性或组织特异性.通过与miRNA特异性的碱基完全或不完全的互补配对,降解其靶基因miRNA或抑制其翻译,从而参与肿瘤细胞的增殖、分化和细胞凋亡过程.miRNA可通过调控其靶基因,影响肿瘤的发生和发展,发挥着类似于癌基因或抑癌基因的功能.目前研究表明,miRNA与肿瘤的发生相关.阐明miRNA与肿瘤基因的关系,对其作为癌症潜在的治疗靶点具有重要意义.
微小RNA(miRNA)是近年來髮現的一類長度為19～25堿基的非編碼小分子單鏈RNA,普遍存在于生物界,在不同物種間具有高度的保守性,其錶達具有細胞特異性或組織特異性.通過與miRNA特異性的堿基完全或不完全的互補配對,降解其靶基因miRNA或抑製其翻譯,從而參與腫瘤細胞的增殖、分化和細胞凋亡過程.miRNA可通過調控其靶基因,影響腫瘤的髮生和髮展,髮揮著類似于癌基因或抑癌基因的功能.目前研究錶明,miRNA與腫瘤的髮生相關.闡明miRNA與腫瘤基因的關繫,對其作為癌癥潛在的治療靶點具有重要意義.
미소RNA(miRNA)시근년래발현적일류장도위19～25감기적비편마소분자단련RNA,보편존재우생물계,재불동물충간구유고도적보수성,기표체구유세포특이성혹조직특이성.통과여miRNA특이성적감기완전혹불완전적호보배대,강해기파기인miRNA혹억제기번역,종이삼여종류세포적증식、분화화세포조망과정.miRNA가통과조공기파기인,영향종류적발생화발전,발휘착유사우암기인혹억암기인적공능.목전연구표명,miRNA여종류적발생상관.천명miRNA여종류기인적관계,대기작위암증잠재적치료파점구유중요의의.
MicroRNA (miRNA)is small non-coding and single-stranded RNA existing in plants and animals with 19-25 nucleotides,miRNA expression is cell or tissue specific.The construction of miRNA has high conservation among different species.MiRNA regulate gene expression by binding with complementary sequences and inhibiting translation of target genes.They participate in tumor cell proliferation,differentiation and apoptosis processes as function as oncogenes or tumor supressor genes.Studies show that the abnormal changes of miRNA expression occurring in tumors,and it is involved in tumor development.Clarifying the relationship of miRNA and tumor gene in the oncogenesis is important for miRNA as potential therapeutic targets.
