CAJ | 학술논문

目的研究HLA配型与尸体肾移植术后早期急性排斥反应的关系.方法将262例尸体肾移植受者按HLA配型的误配率(MM)进行分组,统计各组术后1～2个月内急性排斥反应的发生次数.结果当MM2＞3时,若接受的器官HLA抗原/基因为可接受性,术后急性排斥反应的发生率为16.4%;若供体器官HLA抗原/基因具免疫原性,则急性排斥反应的发生率为33.1%,两者比较,P＜0.05.结论供受者间HLA配型越好,供者器官所含的具免疫原性抗原/基因对术后早期急性排斥反应发生的影响越弱.
목적 연구HLA배형여시체신이식술후조기급성배척반응적관계.방법 장262례시체신이식수자안HLA배형적오배솔(MM)진행분조,통계각조술후1～2개월내급성배척반응적발생차수.결과 당MM2＞3시,약접수적기관HLA항원/기인위가접수성,술후급성배척반응적발생솔위16.4%;약공체기관HLA항원/기인구면역원성,칙급성배척반응적발생솔위33.1%,량자비교,P＜0.05.결론 공수자간HLA배형월호,공자기관소함적구면역원성항원/기인대술후조기급성배척반응발생적영향월약.
Objective To study the relationship between HLA typing and early rejection after cadarer donor kidney transplantation.Methods The 262 recipients undergoing cadaver donor kidney transplantation were randomly grouped in terms of the HLA mismatching(MM)of donors with pen-nissible antigen or irnmunogenic antigen.The incidence of early rejection in 1 to 2 months after operation was analyzed.Results When the MM＞3,if the received organ HLA antigen/gene was permissible.the incidence of postoperative acute rejection was 16.4%;but if the donor organ HLA antigen/gene was immunogenic,the incidence was 33.1%(P＜0.05).Conclusion The better HLA matching of donor-recipient,the fewer influence of HLA mismatching with permissible antigen or immunogenic antigen on early rejection.