CAJ | 학술논문

目的探讨血清同型半胱氨酸(Hcy)与小儿特发性癫痫的相关性.方法将81例小儿特发性癫痫患儿(研究组)的血清Hcy水平与48例健康儿童(对照组)进行对比分析.结果研究组81例癫痫患儿的Hcy水平为7.6～22.0 μmol/L,平均(15.91±2.38)μmol/L,而对照组48例健康儿童的Hcy水平为3～9 μmol/L,平均(6.87±1.75)μmol/L.两组间差异有统计学意义(P＜0.05).对照组小儿仅有6例Hcy水平高于15 μmol/L,而研究组中有73例Hcy水平高于15 μmol/L,差异有统计学意义(P＜0.05).同时全身强直-阵挛性发作和简单或复杂性部分性发作两种癫痫之间的Hcy水平差异无统计学意义(P＞0.05).结论小儿特发性癫痫与高Hcy血症存在显著关系,在对小儿特发性癫痫患临床治疗时,应密切监控患儿的血清Hcy水平,及时促进Hcy体内代谢.
목적 탐토혈청동형반광안산(Hcy)여소인특발성전간적상관성.방법 장81례소인특발성전간환인(연구조)적혈청Hcy수평여48례건강인동(대조조)진행대비분석.결과 연구조81례전간환인적Hcy수평위7.6～22.0 μmol/L,평균(15.91±2.38)μmol/L,이대조조48례건강인동적Hcy수평위3～9 μmol/L,평균(6.87±1.75)μmol/L.량조간차이유통계학의의(P＜0.05).대조조소인부유6례Hcy수평고우15 μmol/L,이연구조중유73례Hcy수평고우15 μmol/L,차이유통계학의의(P＜0.05).동시전신강직-진련성발작화간단혹복잡성부분성발작량충전간지간적Hcy수평차이무통계학의의(P＞0.05).결론 소인특발성전간여고Hcy혈증존재현저관계,재대소인특발성전간환림상치료시,응밀절감공환인적혈청Hcy수평,급시촉진Hcy체내대사.
Objective To study the clinical significance of determination on homocysteine in serum of pediatric idiopathic epilepsy. Methods The homocysteine level in serum of 81 patients with pediatric idiopathic epilepsy was determined,and the value of normal children was tested and compared as control. Results The concentration of Hey in research group was from 7.6mol/L to 22.0μmol/L,the mean value was(15.91 ±2.38)μmol/L,The concentration of Hcy in control group was from 3μmol/L to 9μmol/L,and the mean value was(6.87 ± 1.75)μmol/L.which showed a significant difference(P＜0.05).By comparison,the high concentration(＞15 μmol/L)of Hcy in control group was only 6 cases,while it was 73 cases in research group,which also showed a significant difference (P＜0.05). Conclusion Hcy level was apparently relevant with occurring rate of pediatric idiopathic epilepsy.In the diagnosed clinical treatment of idiopathic epilepsy,the closely monitor of serum level of homocysteine,and timely promoting Hcy metabolism.should be carried out.