中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2009年
19期
28-30
,共3页
脑梗塞%脑血管障碍%蛋白质前体,血栓形成%诊断
腦梗塞%腦血管障礙%蛋白質前體,血栓形成%診斷
뇌경새%뇌혈관장애%단백질전체,혈전형성%진단
Brain infarction%Cerebrovascular disorders%Protein Precurgors,thrombosis%Diagnosis
目的 研究血栓前体蛋白(TpP)在急性缺血性脑血管病早期诊断中的价值.方法 动态观察发病6 h内表现为完全或部分前循环梗死的患者,分为血栓形成性脑梗死(TCI)组40例、短暂性脑缺血发作(TIA)组42例、腔隙性脑梗死(LI)组37例.测定三组患者入院时血浆TpP水平并进行比较.采用ROC曲线分析血浆TpP水平对发病6 h内TCI的诊断价值.结果 TCI、TIA、LI组血浆TpP水平分别为(24.43±3.21)、(15.51±2.65)、(13.52±5.45)mg/L,均显著高于健康人(3.9±2.5)mg/L(P<0.01),TCI组血浆TpP水平显著高于TIA组和LI组(P<0.01),TIA组血浆TpP水平高于LI组(P<0.01). TpP诊断TCI的ROC曲线下面积为0.979±0.013(P<0.01).最佳截断点血浆TpP水平为19.1 mg/L.当血浆TpP水平>19.1 mg/L时,诊断TCI的灵敏度为95%,特异度为96%,二者之和最大.结论 血浆TpP水平可以在发病6 h内鉴别TCI、TIA与Li.
目的 研究血栓前體蛋白(TpP)在急性缺血性腦血管病早期診斷中的價值.方法 動態觀察髮病6 h內錶現為完全或部分前循環梗死的患者,分為血栓形成性腦梗死(TCI)組40例、短暫性腦缺血髮作(TIA)組42例、腔隙性腦梗死(LI)組37例.測定三組患者入院時血漿TpP水平併進行比較.採用ROC麯線分析血漿TpP水平對髮病6 h內TCI的診斷價值.結果 TCI、TIA、LI組血漿TpP水平分彆為(24.43±3.21)、(15.51±2.65)、(13.52±5.45)mg/L,均顯著高于健康人(3.9±2.5)mg/L(P<0.01),TCI組血漿TpP水平顯著高于TIA組和LI組(P<0.01),TIA組血漿TpP水平高于LI組(P<0.01). TpP診斷TCI的ROC麯線下麵積為0.979±0.013(P<0.01).最佳截斷點血漿TpP水平為19.1 mg/L.噹血漿TpP水平>19.1 mg/L時,診斷TCI的靈敏度為95%,特異度為96%,二者之和最大.結論 血漿TpP水平可以在髮病6 h內鑒彆TCI、TIA與Li.
목적 연구혈전전체단백(TpP)재급성결혈성뇌혈관병조기진단중적개치.방법 동태관찰발병6 h내표현위완전혹부분전순배경사적환자,분위혈전형성성뇌경사(TCI)조40례、단잠성뇌결혈발작(TIA)조42례、강극성뇌경사(LI)조37례.측정삼조환자입원시혈장TpP수평병진행비교.채용ROC곡선분석혈장TpP수평대발병6 h내TCI적진단개치.결과 TCI、TIA、LI조혈장TpP수평분별위(24.43±3.21)、(15.51±2.65)、(13.52±5.45)mg/L,균현저고우건강인(3.9±2.5)mg/L(P<0.01),TCI조혈장TpP수평현저고우TIA조화LI조(P<0.01),TIA조혈장TpP수평고우LI조(P<0.01). TpP진단TCI적ROC곡선하면적위0.979±0.013(P<0.01).최가절단점혈장TpP수평위19.1 mg/L.당혈장TpP수평>19.1 mg/L시,진단TCI적령민도위95%,특이도위96%,이자지화최대.결론 혈장TpP수평가이재발병6 h내감별TCI、TIA여Li.
Objective To study the value of thromhus precursor protein(TpP)in early diagnosis of acute ischemic cerebrovascular disease.Methods The patients who showed completely or partly anterior circulation infarcts syndrome and were within 6 hours from onset on admission were observed dynamically.All patients were divided into thrombotic cerebral infarction(TCI)group(40 cases),transient ischemic attack (TIA)group(42 cases), and lacunar infarction(LI)group(37 cases).Concentrations of TpP in plasma obtained from three groups on admission were detected by enzyme linked immunosorbent assay(ELISA),then were compared with each other.The diagnostic value of plasma TpP to TCI within 6 hours from onset was analyzed with ROC curve.Results The level of TpP in TCI,TIA and LI group was(24.43±3.21),(15.51±2.65)and(13.52±5.45)mg/L respectively,and was significantly higher than that of healthy people (3.9±2.5)mg/L(P<0.01).The level of TpP was significantly higher in TCI group than that in TIA and LI group(P<0.01).The level of TpP was significantly higher in TIA group than that in LI group(P<0.01).The area under ROC curve for TpP to diagnose TCI was 0.979±0.013(P<0.01).The level of TpP on optimal cutoff was 19.1 mg/L.When the level of TpP was over 19.1 mg/L,TCI was determined with 95% sensitivity and 96%specificity, sum of which was largest of all.Conclusion The level of TpP can differentiate TCI from TIA and LI within 6 hours from onset.
