实用肝脏病杂志
實用肝髒病雜誌
실용간장병잡지
JOURNAL OF CLINICAL HEPATOLOGY
2013年
4期
351-353
,共3页
郑盛%唐映梅%尤丽英%杨晋辉
鄭盛%唐映梅%尤麗英%楊晉輝
정성%당영매%우려영%양진휘
肝细胞癌%门静脉癌栓%肝动脉插管化疗栓塞%门静脉化疗
肝細胞癌%門靜脈癌栓%肝動脈插管化療栓塞%門靜脈化療
간세포암%문정맥암전%간동맥삽관화료전새%문정맥화료
Hepatocellular carcinoma%Portal vein tumor thrombus%Transcatheter arterial chmoembolization%Portal vein chemotherapy
目的探讨经药物传输泵(DDS)门静脉化疗(PVC)联合肝动脉插管化疗栓塞(TACE)]治疗肝细胞癌伴门静脉癌栓的临床疗效及安全性。方法对87例肝细胞癌合并门静脉癌栓患者手术切除肿瘤并取出癌栓,再随机将患者分成3组。A组行TACE、B组行经DDS泵PVC,C组行经DDS泵PVC联合TACE。随访3年。结果 C组患者术后6个月、1年、2年和3年无瘤生存率分别为93.5%、80.6%、41.9%和29.0%,累积生存率分别为96.8%、87.1%、54.8%和45.2%,其中2年和3年生存率显著高于A组和B组(P均<0.05);C组患者术后6个月、1年、2年和3年上消化道出血发生率分别为0%、0%、16.1%和22.6%,与A组和B组比无显著性差异(P均>0.05)。结论对肝细胞癌合并门静脉癌栓患者行手术切除肿瘤并取出癌栓后,行双途径化疗可有效提高患者无瘤生存率及累计生存率。
目的探討經藥物傳輸泵(DDS)門靜脈化療(PVC)聯閤肝動脈插管化療栓塞(TACE)]治療肝細胞癌伴門靜脈癌栓的臨床療效及安全性。方法對87例肝細胞癌閤併門靜脈癌栓患者手術切除腫瘤併取齣癌栓,再隨機將患者分成3組。A組行TACE、B組行經DDS泵PVC,C組行經DDS泵PVC聯閤TACE。隨訪3年。結果 C組患者術後6箇月、1年、2年和3年無瘤生存率分彆為93.5%、80.6%、41.9%和29.0%,纍積生存率分彆為96.8%、87.1%、54.8%和45.2%,其中2年和3年生存率顯著高于A組和B組(P均<0.05);C組患者術後6箇月、1年、2年和3年上消化道齣血髮生率分彆為0%、0%、16.1%和22.6%,與A組和B組比無顯著性差異(P均>0.05)。結論對肝細胞癌閤併門靜脈癌栓患者行手術切除腫瘤併取齣癌栓後,行雙途徑化療可有效提高患者無瘤生存率及纍計生存率。
목적탐토경약물전수빙(DDS)문정맥화료(PVC)연합간동맥삽관화료전새(TACE)]치료간세포암반문정맥암전적림상료효급안전성。방법대87례간세포암합병문정맥암전환자수술절제종류병취출암전,재수궤장환자분성3조。A조행TACE、B조행경DDS빙PVC,C조행경DDS빙PVC연합TACE。수방3년。결과 C조환자술후6개월、1년、2년화3년무류생존솔분별위93.5%、80.6%、41.9%화29.0%,루적생존솔분별위96.8%、87.1%、54.8%화45.2%,기중2년화3년생존솔현저고우A조화B조(P균<0.05);C조환자술후6개월、1년、2년화3년상소화도출혈발생솔분별위0%、0%、16.1%화22.6%,여A조화B조비무현저성차이(P균>0.05)。결론대간세포암합병문정맥암전환자행수술절제종류병취출암전후,행쌍도경화료가유효제고환자무류생존솔급루계생존솔。
Objective To observe the survival of patients with hepatocellular carcinoma(HCC)complicated by portal vein tumor thrombus (PVTT)receiving transcatheter arterial chemoembolization (TACE)and portal vein chemotherapy(PVC)after resection of tumors. Methods Eighty-seven patients with HCC complicated by PVTT had tumor resection and removal of PVTT. After the operation,the patients were randomly divided into three groups. The patients in group A,B and C were treated by TACE,by PVC and by TACE combined with PVC,respectively. The patients in the three groups were followed-up for three years. Results The tumor free survivals in group C six months,one year,two years and three years after the treatment were 93.5%,80.6%,41.9% and 29.0%,and the accumulative survival rates were 96.8%,87.1%,54.8% and 45.2%,respectively. Out of them,the survivals at two and three years were much higher than those in group B and C (P<0.05);the incidence of upper gastrointestinal bleeding in group C in six months,one year,two years and three years were 0%,0%,16.1% and 22.6%,respec-tively,without significant difference as compared to those in group A and B (P均>0.05). Conclusion The TACE and PVC are alternative approach in patients with HCC complicated by PVTT,which might improve the tumor-free survival and the accumulative survival rates.