CAJ | 학술논문

神经介素U首次是从猪脊髓中分离得到并提纯的,在体内分布广泛,主要分布在胃肠道和中枢,其受体为G蛋白耦联受体的配体FM-3和FM-4,即神经介素U受体1和神经介素U受体2.最近研究发现,神经介素U为内源性抑食肽,具有抑制摄食、增加自主活动、促进机体代谢、调节能量平衡的作用.本文主要介绍神经介素U及其受体在摄食调控方面的研究.
신경개소U수차시종저척수중분리득도병제순적,재체내분포엄범,주요분포재위장도화중추,기수체위G단백우련수체적배체FM-3화FM-4,즉신경개소U수체1화신경개소U수체2.최근연구발현,신경개소U위내원성억식태,구유억제섭식、증가자주활동、촉진궤체대사、조절능량평형적작용.본문주요개소신경개소U급기수체재섭식조공방면적연구.
Neuromedin U,first isolated from porcine spinal cord,is widely distributed with highest expression in the gastrointestinal tract and the central nervous system.Its receptors are the endogenous ligands for two G protein-coupled receptors,FM-3 (neuromedin U receptor 1) and FM-4 (neuromedin U receptor 2).Recently,neuromedin U is found to be as an endogenous anorexigenic peptide.It can inhibit food intake,increase the locomotor activity,promote the metabolism of the body and regulate energy homeostasis.This review mainly introduces the roles of neuromedin U and its two receptors in regulation of food intake.