CAJ | 학술논문

目的探讨吸烟对脑梗死患者血液中低密度脂蛋白(LDL)体外氧化延迟时间的影响.方法急性脑梗死患者67例,其中37例有吸烟史者作为吸烟组,30例无吸烟史者作为对照组,两组年龄、性别、血压、血脂、血糖及病灶部位、大小和程度差异无统计学意义(均P>0.05).分析测定所有受试者血液中LDL体外氧化延迟时间及空腹静脉血中LDL-总胆固醇、LDL-甘油三酯(TO)、LDL-游离胆固醇水平.结果吸烟组LDL体外氧化延迟时间明显短于对照组[(77.21±9.1)min和(59.95±8.7)min,P<0.001].吸烟组LDL-总胆固醇、LDL-甘油三酯、LDL-游离胆固醇与对照组比较差异无统计学意义(分别为5.12±0.61与4.63±0.62 mmol/L;0.89±0.07 mmol/L与0.85±0.04 mmol/L;1.71 ±0.43与1.74±0.91 mmol/L,均P>0.05).结论吸烟可以使脑梗死患者血液中LDL体外氧化延迟时间缩短,减弱LDL的抗氧化能力,加重机体的氧化压力.
목적 탐토흡연대뇌경사환자혈액중저밀도지단백(LDL)체외양화연지시간적영향.방법 급성뇌경사환자67례,기중37례유흡연사자작위흡연조,30례무흡연사자작위대조조,량조년령、성별、혈압、혈지、혈당급병조부위、대소화정도차이무통계학의의(균P>0.05).분석측정소유수시자혈액중LDL체외양화연지시간급공복정맥혈중LDL-총담고순、LDL-감유삼지(TO)、LDL-유리담고순수평.결과 흡연조LDL체외양화연지시간명현단우대조조[(77.21±9.1)min화(59.95±8.7)min,P<0.001].흡연조LDL-총담고순、LDL-감유삼지、LDL-유리담고순여대조조비교차이무통계학의의(분별위5.12±0.61여4.63±0.62 mmol/L;0.89±0.07 mmol/L여0.85±0.04 mmol/L;1.71 ±0.43여1.74±0.91 mmol/L,균P>0.05).결론 흡연가이사뇌경사환자혈액중LDL체외양화연지시간축단,감약LDL적항양화능력,가중궤체적양화압력.
Objective To study the effect of smoking on oxidized low-density lipoprotein ox-LDL lag time in patients with cerebral infarction. Methods Plasma samples were obtained from 67 patients with cerebral infarc-tion. 30 acute cerebral infarction patients without history of smoking were chosen to be as control group; meanwhile, 37 acute cerebral infarction patients with history of smoking were chosen to be as smoking group. There was no statis-tical difference in age,gender,blood pressure,lipid level and location and level of the cerebral focus between the two groups (P > 0.05). The ox-LDL lag time and lipid levels of low-density lipoproteins (LDL), including total choles-terol (TC) ,triglyceride (TG) and free cholesterol were measured. Results The ox-LDL lag time of the patients with history of smoking was significantly shorter than that in the control group[(77.21 ± 9.1) min vs. (59.95 ± 8.7)min,P <0.001]. There were no significant differences in LDL- TC,LDL- TG and LDL-free cholesterol level[(5.12±0.61) vs. (4.63±0.62) mmol/L; (0.89±0.07) mmol/L vs. (0.85±0.04) mmol/L; (1.71±0.43) vs. (1.74±0.91) mmol/L, P > 0.05 respectively] between the two groups. Conclusion Smoking shorts the ox-LDL lag time in patients with cerebral infarction, and decrease the anti-oxidization and increase the stress of oxidization.