中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2010年
5期
494-496
,共3页
肺源性心脏病%心力衰竭%参附注射液
肺源性心髒病%心力衰竭%參附註射液
폐원성심장병%심력쇠갈%삼부주사액
Pulmonary heart disease%Heart failure%Shenfu injection
目的 观察参附注射液治疗气虚血淤型慢性肺源性心脏病合并心力衰竭的临床疗效.方法 采用随机对照法将96例患者分为治疗组56例和对照组40例,2组均给予基础治疗,治疗组在基础治疗的基础上加用参附注射液60～80 ml加入5%葡萄糖注射液或0.9%的氯化钠注射液150 ml中静脉滴注,15 d为一疗程,共2个疗程.观察2组治疗前后中医症候以及左心室射血分数(LVEF)、B型尿钠肽(BNP)的变化.结果治疗组临床总有效率达91.1%(51/56),明显高于对照组[72.5%(29/40),x2=8.545,P＜0.05];治疗后治疗组LVEF明显高于对照组[(53.27±7.45)%与(49.12±5.89)%,t=2.165,P＜0.05],BNP较对照组明显降低[(209.1±18.7)、(261.2±19.3)ng/L,t=2.284,P＜0.05].结论 参附注射液能增强心肌收缩力,增加LVEF,从而显著改善左心室功能;降低BNP,纠正心力衰竭.
目的 觀察參附註射液治療氣虛血淤型慢性肺源性心髒病閤併心力衰竭的臨床療效.方法 採用隨機對照法將96例患者分為治療組56例和對照組40例,2組均給予基礎治療,治療組在基礎治療的基礎上加用參附註射液60～80 ml加入5%葡萄糖註射液或0.9%的氯化鈉註射液150 ml中靜脈滴註,15 d為一療程,共2箇療程.觀察2組治療前後中醫癥候以及左心室射血分數(LVEF)、B型尿鈉肽(BNP)的變化.結果治療組臨床總有效率達91.1%(51/56),明顯高于對照組[72.5%(29/40),x2=8.545,P＜0.05];治療後治療組LVEF明顯高于對照組[(53.27±7.45)%與(49.12±5.89)%,t=2.165,P＜0.05],BNP較對照組明顯降低[(209.1±18.7)、(261.2±19.3)ng/L,t=2.284,P＜0.05].結論 參附註射液能增彊心肌收縮力,增加LVEF,從而顯著改善左心室功能;降低BNP,糾正心力衰竭.
목적 관찰삼부주사액치료기허혈어형만성폐원성심장병합병심력쇠갈적림상료효.방법 채용수궤대조법장96례환자분위치료조56례화대조조40례,2조균급여기출치료,치료조재기출치료적기출상가용삼부주사액60～80 ml가입5%포도당주사액혹0.9%적록화납주사액150 ml중정맥적주,15 d위일료정,공2개료정.관찰2조치료전후중의증후이급좌심실사혈분수(LVEF)、B형뇨납태(BNP)적변화.결과치료조림상총유효솔체91.1%(51/56),명현고우대조조[72.5%(29/40),x2=8.545,P＜0.05];치료후치료조LVEF명현고우대조조[(53.27±7.45)%여(49.12±5.89)%,t=2.165,P＜0.05],BNP교대조조명현강저[(209.1±18.7)、(261.2±19.3)ng/L,t=2.284,P＜0.05].결론 삼부주사액능증강심기수축력,증가LVEF,종이현저개선좌심실공능;강저BNP,규정심력쇠갈.
Objective To assess the clinical effects of Shenfu injection which consists mainly of panaxoside and water-solubility alkaloied on chronic pulmonary heart disease complicated with heart failure.Methods Ninetysix patients were randomly divided into two groups ,40 patients underwent regular treatment (control group) and 56 patients were treated with Shenfu injection additionally to regular treatment (treatment group ).There were 2 treatment durations,with 15 days in one duration.The symptoms,left ventricular ejection fraction (LVEF) and B type UNa peptide (BNP) were measured before and after treatment.Results The total effective rate in the treatment group was 91.1% (51/56) ,which was significantly higher than that in the control group (72.5% ,29/40) (P ＜0.05 ).After treatment,the treatment group has significantly higher LVEF than the control group(53.27% ±7.45%vs.49.12% ± 5.89% ) ( P ＜ 0.05 ),and significantly lower BNP ( ( 209.1 ± 18.7 ) ng/L vs.( 261.2 ± 19.3 ) ng/L ( P ＜ 0.05).Conclusions Shenfu injection could strengthen the contractility and increase LVEF,therefore improve the function of left ventricle,as well as decrease BNP and repair heart failure.
