中华眼视光学与视觉科学杂志
中華眼視光學與視覺科學雜誌
중화안시광학여시각과학잡지
CHINESE JOURNAL OF OPTOMETRY OPHTHALMOLOGY AND VISUAL SCIENCE
2012年
5期
272-275
,共4页
干皮病%着色性%眼眶%肿瘤%继发原发性%眼外科手术%免疫组织化学
榦皮病%著色性%眼眶%腫瘤%繼髮原髮性%眼外科手術%免疫組織化學
간피병%착색성%안광%종류%계발원발성%안외과수술%면역조직화학
Xeroderma pigmentosum%Obital%Neoplasms%second primary%Ophthalmologic surgical procedure%Immunohistochemistry
目的 探讨着色性干皮病继发眼部恶性肿瘤的临床、病理、手术治疗方法及预后.方法 回顾性病例研究.1999-2008年间收治的着色性干皮病继发眼部恶性肿瘤患者5例,平均年龄(44.6±4.9)岁,采用手术治疗,并对这些患者的手术方式、肿瘤病理学检查和免疫组化检查结果进行分析.结果 病理学及免疫组化检查显示结膜角膜黑色素瘤1例,基底细胞癌3例,恶性神经鞘瘤1例.5例患者随访3～6年、2例术后再发肿瘤,l例为毛发上皮瘤,1例为鳞状细胞癌.结论 继发于着色性干皮病的眼部肿瘤多为恶性,有复发倾向,虽然眼部并发的恶性肿瘤发病进展快、预后差,但及时的手术干预,可以明显改善预后.术中可根据冰冻病理检查,对已发生癌变者行大面积切除、植皮,手术治疗范围要足够大.
目的 探討著色性榦皮病繼髮眼部噁性腫瘤的臨床、病理、手術治療方法及預後.方法 迴顧性病例研究.1999-2008年間收治的著色性榦皮病繼髮眼部噁性腫瘤患者5例,平均年齡(44.6±4.9)歲,採用手術治療,併對這些患者的手術方式、腫瘤病理學檢查和免疫組化檢查結果進行分析.結果 病理學及免疫組化檢查顯示結膜角膜黑色素瘤1例,基底細胞癌3例,噁性神經鞘瘤1例.5例患者隨訪3～6年、2例術後再髮腫瘤,l例為毛髮上皮瘤,1例為鱗狀細胞癌.結論 繼髮于著色性榦皮病的眼部腫瘤多為噁性,有複髮傾嚮,雖然眼部併髮的噁性腫瘤髮病進展快、預後差,但及時的手術榦預,可以明顯改善預後.術中可根據冰凍病理檢查,對已髮生癌變者行大麵積切除、植皮,手術治療範圍要足夠大.
목적 탐토착색성간피병계발안부악성종류적림상、병리、수술치료방법급예후.방법 회고성병례연구.1999-2008년간수치적착색성간피병계발안부악성종류환자5례,평균년령(44.6±4.9)세,채용수술치료,병대저사환자적수술방식、종류병이학검사화면역조화검사결과진행분석.결과 병이학급면역조화검사현시결막각막흑색소류1례,기저세포암3례,악성신경초류1례.5례환자수방3～6년、2례술후재발종류,l례위모발상피류,1례위린상세포암.결론 계발우착색성간피병적안부종류다위악성,유복발경향,수연안부병발적악성종류발병진전쾌、예후차,단급시적수술간예,가이명현개선예후.술중가근거빙동병리검사,대이발생암변자행대면적절제、식피,수술치료범위요족구대.
Objective To investigate clinical manifestations,pathology,surgical treatment and prognosis of oculocutaneous malignancy secondary to xeroderma pigmentosum.Methods This was a retrospective case series study.The case records of 5 malignancy patients secondary to xeroderma pigmentosum visited Beijing Tongren Eye Center between 1999 and 2011 were reviewed,and the mean age of the patients was 44.6±4.9 years.Surgical and other treatment and immunohistochemical staining were analyzed.Results The results of pathological and immunohistochemical examinations showed that 1 case had malignant neurinoma,and 3 cases had basal cell carcinoma,and 1 case had malignant melanocytoma.All these cases were followed-up for 3 to 6 years.In 2 cases the malignancy relapsed,one was squamous cell carcinoma,another trichoepithelioma.Conclusion Oculocutaneous tumor secondary to xeroderma pigmentosum usually is malignant,and tends to recur.Although the characteristics of this disease include a rapidly progressive clinical course of the malignant tumor in the eye and a poor prognosis,timely surgical removal will significantly improve the prognosis.Massive resction and skin grafting should be performed during the surgery according to the results of pathological examination on the cryostat sections,and the range of surgical treatment should be large enough.
