CAJ | 학술논문

丁基苯酞是我国脑血管领域第一个拥有自主知识产权的一类新药,常温下为一种淡黄色或者无色粘稠油状液体,具有众多优点,但在临床使用中会出现转氨酶升高、肝功能异常和消化道反应等不良反应.将卤素原子引入到丁基苯酞的6位,获得了3个固态的丁基苯酞类似物,并对其进行了IR和Raadn光谱测定.两种光谱提供了互为补充的信息,引入卤原子后,双取代苯环的特征峰消失,出现了三取代苯环的特征峰.在红外中比较弱甚至检测不到的3位C-H伸缩振动在Raman中非常明显,在Ranman的低波数区间检测到了可被指认为-C-C-C-C-的变形振动.根据这两种光谱的研究结果确认了所合成化合物的结构.
정기분태시아국뇌혈관영역제일개옹유자주지식산권적일류신약,상온하위일충담황색혹자무색점주유상액체,구유음다우점,단재림상사용중회출현전안매승고、간공능이상화소화도반응등불량반응.장서소원자인입도정기분태적6위,획득료3개고태적정기분태유사물,병대기진행료IR화Raadn광보측정.량충광보제공료호위보충적신식,인입서원자후,쌍취대분배적특정봉소실,출현료삼취대분배적특정봉.재홍외중비교약심지검측불도적3위C-H신축진동재Raman중비상명현,재Ranman적저파수구간검측도료가피지인위-C-C-C-C-적변형진동.근거저량충광보적연구결과학인료소합성화합물적결구.
dl-NBP is a potentially beneficial and promising drug for treatment of ischemic stroke with multiple actions that affect different pathophysiologic processes, such as improving microcirculation, decreasing brain infarct volume, regulating energy metabolism, and especially inhibiting platelet aggregation and reducing thrombus formation. However, NBP is limited to use in the clinic by other side effects, such as elevated aminotransferase, abnormal liver function and digestive response. Some derivates of NBP were synthesized with the halides (F, Cl and Br) on the 6-position, and their IR and Raman spectra were measured. They proved the complemental information for deducing their structure. By comparing the spectra of the NBP, the band of disubstitut-ed benzene disappeared in the derivatives, and the band of trisubstituted benzenes were observed. The stretching vibrational band of C-H was detected in the Raman spectra, but was not observed in IR. In the low frequency region, the deformation vibration band of -C-C-C-C was also observed in the Raman spectra.