CAJ | 학술논문

目的分析不同病理分型、不同临床分期的肺癌患者中促血管生成素-2(Ang-2)的表达水平,进一步探讨该病的发病机理,为临床诊断提供依据.方法对112例肺癌患者,16例健康体检者进行血清Ang-2检测,同时进行血清中其他相关肿瘤标志物检测.比较不同病理分型、临床分期及远处转移患者血清Ang-2的不同.结果非小细胞肺癌患者血清Ang-2水平高于正常对照组(与鳞癌比较Sig 值为0.049,P＜0.05;与腺癌比较Sig值为0.011,P＜0.05)；非小细胞肺癌Ⅲ、Ⅳ期患者血清Ang-2水平高于对照(与Ⅲ期比较Sig值为0.013,P＜0.05;与Ⅳ期比较Sig值为0.000,P＜0.001)；远处转移患者血清Ang-2水平非常显著高于非远处转移者(Sig值为0.008,P＜0.01)；结论分析血清Ang-2水平对肺癌患者的临床诊断、预测转移和预后判断均有临床价值,应用Ang-2与其他肿瘤标志物联合检测可提高患者诊断阳性率.
목적 분석불동병리분형、불동림상분기적폐암환자중촉혈관생성소-2(Ang-2)적표체수평,진일보탐토해병적발병궤리,위림상진단제공의거.방법 대112례폐암환자,16례건강체검자진행혈청Ang-2검측,동시진행혈청중기타상관종류표지물검측.비교불동병리분형、림상분기급원처전이환자혈청Ang-2적불동.결과 비소세포폐암환자혈청Ang-2수평고우정상대조조(여린암비교Sig 치위0.049,P＜0.05;여선암비교Sig치위0.011,P＜0.05)；비소세포폐암Ⅲ、Ⅳ기환자혈청Ang-2수평고우대조(여Ⅲ기비교Sig치위0.013,P＜0.05;여Ⅳ기비교Sig치위0.000,P＜0.001)；원처전이환자혈청Ang-2수평비상현저고우비원처전이자(Sig치위0.008,P＜0.01)；결론 분석혈청Ang-2수평대폐암환자적림상진단、예측전이화예후판단균유림상개치,응용Ang-2여기타종류표지물연합검측가제고환자진단양성솔.
Objective To analyze angiopoietin-2 (Ang-2) level in lung cancer patients with different pathological types and clinical staging,and further to elaborate the pathogenesis of lung cancer and provide a basis for clinical diagnosis.Methods Serum angiopoietin-2 and other tumor associated markers were measured in 112 lung cancer patients and 16 healthy volunteers.Ang-2 levels were compared in patients with different pathological types,clinical stages and distant metastasis.Results The level of serum Ang-2 was higher in lung cancer patients compared with controls (Sig =0.049,0.011,P ＜0.05).The Ang-2 level was higher in patients with stage Ⅲ/Ⅳ nonsmall-cell lung cancer(NSCLC) than controls ( compared with stage Ⅲ,Sig =0.013,P ＜ 0.05 ;compared with stageⅣ,Sig =0.000,P ＜ 0.001 ),Patients with distant metastasis had higher level of Ang-2 than those without metastasis.Conclusions Ang-2 is a useful clinical marker for diagnosis and prognosis of lung cancer,as well as predicting the metastasis.In combination with the other tumor markers,Ang-2 can improve the rate of diagnosis of lung cancer.