国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2011年
3期
177-179,183
,共4页
胰腺衍生因子%β细胞%细胞凋亡%糖尿病
胰腺衍生因子%β細胞%細胞凋亡%糖尿病
이선연생인자%β세포%세포조망%당뇨병
Pancreatic derived factor%β-cell%Apoptosis%Diabetes mellitus
胰腺衍生因子(pancreatic derived factor,PANDER)是2002年新发现的细胞因子,主要表达于胰腺β细胞和α细胞.在β细胞内,PANDER与胰岛素共同定位于胰岛素分泌颗粒中.葡萄糖、转录因子及细胞因子可调节PANDER mRNA的表达,葡萄糖及胰岛素促分泌剂可促进PANDER的分泌.PANDER可诱导β细胞凋亡,对基础胰岛索分泌有迟发抑制作用.在抑制肝细胞胰岛素信号转导、促进肝细胞脂肪变性及调节肝糖原代谢方面,PANDER也起着重要作用.
胰腺衍生因子(pancreatic derived factor,PANDER)是2002年新髮現的細胞因子,主要錶達于胰腺β細胞和α細胞.在β細胞內,PANDER與胰島素共同定位于胰島素分泌顆粒中.葡萄糖、轉錄因子及細胞因子可調節PANDER mRNA的錶達,葡萄糖及胰島素促分泌劑可促進PANDER的分泌.PANDER可誘導β細胞凋亡,對基礎胰島索分泌有遲髮抑製作用.在抑製肝細胞胰島素信號轉導、促進肝細胞脂肪變性及調節肝糖原代謝方麵,PANDER也起著重要作用.
이선연생인자(pancreatic derived factor,PANDER)시2002년신발현적세포인자,주요표체우이선β세포화α세포.재β세포내,PANDER여이도소공동정위우이도소분비과립중.포도당、전록인자급세포인자가조절PANDER mRNA적표체,포도당급이도소촉분비제가촉진PANDER적분비.PANDER가유도β세포조망,대기출이도색분비유지발억제작용.재억제간세포이도소신호전도、촉진간세포지방변성급조절간당원대사방면,PANDER야기착중요작용.
Pancreatic derived factor (PANDER) is a new cytokine cloned in 2002 with highly specific expression in pancreatic β- and α-cells. PANDER appears to colocalize to the insulin-containing secretory granules with insulin in β-cells. PANDER mRNA expression is regulated by glucose,transcriptional factors and cytokines. The secretion of PANDER is induced by glucose and insulin secretagogues. PANDER can induce the apoptosis of β-cells, and has delayed effects on inhibiting basal insulin secretion. PANDER also plays an important role in inhibiting insulin signaling in the liver cells,promoting hepatic steatosis and regulating hepatic glycogen metabolism.
