中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
3期
319-320
,共2页
皮肤疾病,水疱大疱性%甲基泼尼松龙%丙种球蛋白
皮膚疾病,水皰大皰性%甲基潑尼鬆龍%丙種毬蛋白
피부질병,수포대포성%갑기발니송룡%병충구단백
Skin diseases,vesiculobullous%Methylprednisolone%Gamma globulin
目的 观察甲基泼尼松龙联合大剂量丙种球蛋白(IVIg)治疗重症大疱性皮肤病的临床效果及安全性.方法 51例重症大疱性皮肤病患者在知情同意情况下,按数字表法随机分为对照组(26例)和观察组(25例),对照组给予甲基泼尼松龙治疗,观察组在此基础上联合应用大剂量注射用IVIg,观察两组临床治疗效果及不良反应发生情况.结果 观察组住院天数(15.6±6.2)d、激素用量(87.6±13.7)mg、激素减量时间(8.6±2.4)d,明显低于对照组的(23.1±6.3)d、(105.3±16.4)mg、(13.8±4.1)d(t=2.771、3.102、3.219,均P＜0.05);观察组总体有效率为96.0%明显高于对照组的84.6%(x2=6.248,P＜0.05);观察组治疗起效时间和皮损明显消退时间分别为(8.9±2.4)d、(17.6±3.7)d,均明显低于对照组的(13.1±3.8)d、(23.6±5.1)d,两组间比较差异均有统计学意义(t=2.893、3.347,均P＜0.05).观察组发生并发症5例低于对照组的9例(x2=5.245,P＜0.05).结论 甲基泼尼松龙联合IVIg治疗重症大疱性皮肤病可以缩短病程、减少并发症发生率、提高治疗有效率,值得临床推广.
目的 觀察甲基潑尼鬆龍聯閤大劑量丙種毬蛋白(IVIg)治療重癥大皰性皮膚病的臨床效果及安全性.方法 51例重癥大皰性皮膚病患者在知情同意情況下,按數字錶法隨機分為對照組(26例)和觀察組(25例),對照組給予甲基潑尼鬆龍治療,觀察組在此基礎上聯閤應用大劑量註射用IVIg,觀察兩組臨床治療效果及不良反應髮生情況.結果 觀察組住院天數(15.6±6.2)d、激素用量(87.6±13.7)mg、激素減量時間(8.6±2.4)d,明顯低于對照組的(23.1±6.3)d、(105.3±16.4)mg、(13.8±4.1)d(t=2.771、3.102、3.219,均P＜0.05);觀察組總體有效率為96.0%明顯高于對照組的84.6%(x2=6.248,P＜0.05);觀察組治療起效時間和皮損明顯消退時間分彆為(8.9±2.4)d、(17.6±3.7)d,均明顯低于對照組的(13.1±3.8)d、(23.6±5.1)d,兩組間比較差異均有統計學意義(t=2.893、3.347,均P＜0.05).觀察組髮生併髮癥5例低于對照組的9例(x2=5.245,P＜0.05).結論 甲基潑尼鬆龍聯閤IVIg治療重癥大皰性皮膚病可以縮短病程、減少併髮癥髮生率、提高治療有效率,值得臨床推廣.
목적 관찰갑기발니송룡연합대제량병충구단백(IVIg)치료중증대포성피부병적림상효과급안전성.방법 51례중증대포성피부병환자재지정동의정황하,안수자표법수궤분위대조조(26례)화관찰조(25례),대조조급여갑기발니송룡치료,관찰조재차기출상연합응용대제량주사용IVIg,관찰량조림상치료효과급불량반응발생정황.결과 관찰조주원천수(15.6±6.2)d、격소용량(87.6±13.7)mg、격소감량시간(8.6±2.4)d,명현저우대조조적(23.1±6.3)d、(105.3±16.4)mg、(13.8±4.1)d(t=2.771、3.102、3.219,균P＜0.05);관찰조총체유효솔위96.0%명현고우대조조적84.6%(x2=6.248,P＜0.05);관찰조치료기효시간화피손명현소퇴시간분별위(8.9±2.4)d、(17.6±3.7)d,균명현저우대조조적(13.1±3.8)d、(23.6±5.1)d,량조간비교차이균유통계학의의(t=2.893、3.347,균P＜0.05).관찰조발생병발증5례저우대조조적9례(x2=5.245,P＜0.05).결론 갑기발니송룡연합IVIg치료중증대포성피부병가이축단병정、감소병발증발생솔、제고치료유효솔,치득림상추엄.
Objective To explore the effect of methylprednisolone combined with high dose immunoglobulin (IVIg) in treatment of severe bullous skin disease. Methods 51 cases of severe bullous skin diseases were randomly divided into control group and observation group and control group received conventional methylprednisolone treatment on the basis of the observation group in this high-dose injection combined with IVIg,therapeutic effect were observed.Results The observation group hospitalization days ( 15.6 ± 6. 2) d, hormone usage ( 87. 6 ± 13.7 ) mg, hormone reduction time(8. 6 ±2. 4) d,were obviously lower than the control group(23. 1 ±6. 3)d,( 105.3 ± 1.64) mg, ( 13.8 ±4. 1 ) d ( t = 2. 771,3. 102,3. 219, P ＜ 0. 05 ). The observation group total effective rate was significantly higher than the control group( x2 =6. 248,P ＜0. 05). The observation group therapy effect-acting period and obviously subsidise lesions time was(8. 9 ±2. 4)d, (17.6 ±3. 7)d respectively,were significantly lower than the control group( 13. 1 ±3. 8) d, (23. 6 ± 5. 1 ) d, the differences between the two groups were statistically significant ( t = 2. 893,3. 347, P ＜0. 05). The observation group complication occurred in 5 cases were lower than those of the control group of 9 cases (x2 = 5.245 ,P ＜ 0. 05 ). Conclusion Methylprednisolone combined with high dose IVIg treatment of severe bullous skin disease could shorten the course and speed up the restoration of skin lesions, reduce and alleviate the glucocorticoid dosage and side effects, improve the cure rate , and it was worthy of promotion.
