CAJ | 학술논문

目的探讨新生儿溶血病D-二聚体水平变化及临床意义。方法选取新生儿溶血病患儿60例，按照胆红素水平分为非重度组（34例）和重度组（26例）。同期出生的40例正常足月儿为对照组。检测各组D-二聚体及纤维蛋白原(FIB)水平的变化。结果重度组、非重度组D-二聚体水平[分别为(9.29±11.34)、(0.84±0.77) mg/L]明显高于对照组[(0.45±0.06) mg/L](P＜ 0.01或＜0.05)，重度组明显高于非重度组(P＜0.01)。各组FIB水平比较差异无统计学意义(P＞0.05)。结论重度新生儿溶血病患儿体内存在高凝状态，血浆D-二聚体水平测定对新生儿溶血病患儿的病情判断和治疗有一定的价值。
목적탐토신생인용혈병D-이취체수평변화급림상의의。방법선취신생인용혈병환인60례，안조담홍소수평분위비중도조（34례）화중도조（26례）。동기출생적40례정상족월인위대조조。검측각조D-이취체급섬유단백원(FIB)수평적변화。결과중도조、비중도조D-이취체수평[분별위(9.29±11.34)、(0.84±0.77) mg/L]명현고우대조조[(0.45±0.06) mg/L](P＜ 0.01혹＜0.05)，중도조명현고우비중도조(P＜0.01)。각조FIB수평비교차이무통계학의의(P＞0.05)。결론중도신생인용혈병환인체내존재고응상태，혈장D-이취체수평측정대신생인용혈병환인적병정판단화치료유일정적개치。
Objective To investigate the change of D-dimer in haemolytic disease of newborn and its clinical significance. Methods Sixty cases with haemolytic disease of newborn were divided into nonserious group(34 cases) and serious group(26 cases) by the level of bilirubin, 40 cases of normal neonatus (control group) were also selected. The levels of D-dimer and fibrinogen(FIB) were measured and compared.Results The level of D-dimer in serious group and non-serious group[ (9.29 ± 11.34), (0.84 ± 0.77 ) mg/L]was higher than that in control group [ (0.45 ± 0.06) mg/L](P ＜ 0.01 or ＜ 0.05 ),the level of D-dimer in serious group was higher than that in non-serious group (P＜ 0.01 ). There was no significant difference in the level of FIB among the three groups (P ＞ 0.05). Conclusions There is hypercoagulability in the serious haemolytic disease of newborn. It is valuable to detect plasma D-dimer density for serious haemolytic disease of judgement and treatment.