CAJ | 학술논문

目的探讨用药形式对高血压病患者依从性的影响,寻求提高血压控制率的方法.方法将160例初发轻中度高血压病患者随机分成固定复方组和简单合用组.固定复方组服用固定复方制剂(成分为厄贝沙坦150 mg/氢氯噻嗪12.5 mg)1 次/d;简单合用组分别服用厄贝沙坦150 mg及氢氯噻嗪12.5 mg.1次/d.观察3个月内2组依从性和临床疗效差别.结果 1个月时固定复方组和简单合用组收缩压分别为(139.4±3.6)和(141.3±5.7)mm Hg,舒张压分别是(83.2±2.1)和(85.5±3.8)mm Hg,2组差异无统计学意义(P>0.05).3个月时固定复方降压药物组依从性达61.5%(48例),收缩压(138.4±2.2)mm Hg,血压达标率56.4%(44例),均明显好于简单合用组[依从性45.6%(36例),收缩压(146.3±2.7)mm Hg,血压达标率46.8%(37例),差异有统计学意义(P<0.05)].结论固定复方制剂降压药物使高血压病患者依从性更好,降压疗效更佳.
목적 탐토용약형식대고혈압병환자의종성적영향,심구제고혈압공제솔적방법.방법 장160례초발경중도고혈압병환자수궤분성고정복방조화간단합용조.고정복방조복용고정복방제제(성분위액패사탄150 mg/경록새진12.5 mg)1 차/d;간단합용조분별복용액패사탄150 mg급경록새진12.5 mg.1차/d.관찰3개월내2조의종성화림상료효차별.결과 1개월시고정복방조화간단합용조수축압분별위(139.4±3.6)화(141.3±5.7)mm Hg,서장압분별시(83.2±2.1)화(85.5±3.8)mm Hg,2조차이무통계학의의(P>0.05).3개월시고정복방강압약물조의종성체61.5%(48례),수축압(138.4±2.2)mm Hg,혈압체표솔56.4%(44례),균명현호우간단합용조[의종성45.6%(36례),수축압(146.3±2.7)mm Hg,혈압체표솔46.8%(37례),차이유통계학의의(P<0.05)].결론 고정복방제제강압약물사고혈압병환자의종성경호,강압료효경가.
Objecfive To compare the effects of fix-combination with simple combination on the antihypertensive activity and compliance.Methods Totally 160 patients with initial mild-moderate essential hypertension were randomized into two groups:fix-combination or simple combination with irbesartan and hydrochlorothiazide groups.The antihypertensive activity and tolerability within three months were monitored.Results Compared with simple combination(141.3±5.7)mm Hg and(85.5±3.8)mm Hg,fix-combination(139.4±3.6)mm Hg and (83.2±2.1)mm Hg did not further decrease the systolic and diastolic blood pressure within 1 month's treatment (P>0.05).However,3 months later,the systolic blood pressure,the rate of reaching blood pressure target and tolerability were improved more in fix-combination group than that in simple combination group(all P<0.05).Conclusion Fix-combination antihypertensive therapy can increase antihypertensive activity and tolerability in patients with initial mild-moderate essential hypertension.