中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2008年
7期
515-518
,共4页
胡晓彤%陈薇%王达%石青岚%张敷彪%廖永强%金梅%何超
鬍曉彤%陳薇%王達%石青嵐%張敷彪%廖永彊%金梅%何超
호효동%진미%왕체%석청람%장부표%료영강%금매%하초
PSMA7%蛋白酶体%结直肠肿瘤%肿瘤转移
PSMA7%蛋白酶體%結直腸腫瘤%腫瘤轉移
PSMA7%단백매체%결직장종류%종류전이
PSMA7%Proteasome%Colorectal neoplasms%Neoplasm metastasis
目的 探讨蛋白酶体亚基PSMA7在大肠癌中的表达及意义.方法 应用免疫组化法检测手术切除的62例原发大肠癌组织、34例转移淋巴结和13例肝转移组织中PSMA7的表达.并分析PSMA7的表达与临床病理之间的关系.结果 PSMA7在正常大肠组织中均为阴性或弱阳性,而在38.7%(24/62)原发大肠癌组织、52.9%(18/34)转移淋巴结和100%(13/13)肝转移组织中高表达,且原发大肠癌组织的PSMA7高表达与肝转移密切相关(P=0.028).PSMA7高表达组的患者生存率明显低于PSMA7低表达组(P=0.0008).在生存率多因素分析中,PSMA7表达为影响患者预后的独立因素(P=0.004,相对危险度5, 057,95%可信区间为1.682-15.201).结论 PSMA7可能在大肠癌的进展中起重要作用,评估原发大肠癌组织中PSMA7的表达水平对判断是否继发肝转移有一定指导意义.
目的 探討蛋白酶體亞基PSMA7在大腸癌中的錶達及意義.方法 應用免疫組化法檢測手術切除的62例原髮大腸癌組織、34例轉移淋巴結和13例肝轉移組織中PSMA7的錶達.併分析PSMA7的錶達與臨床病理之間的關繫.結果 PSMA7在正常大腸組織中均為陰性或弱暘性,而在38.7%(24/62)原髮大腸癌組織、52.9%(18/34)轉移淋巴結和100%(13/13)肝轉移組織中高錶達,且原髮大腸癌組織的PSMA7高錶達與肝轉移密切相關(P=0.028).PSMA7高錶達組的患者生存率明顯低于PSMA7低錶達組(P=0.0008).在生存率多因素分析中,PSMA7錶達為影響患者預後的獨立因素(P=0.004,相對危險度5, 057,95%可信區間為1.682-15.201).結論 PSMA7可能在大腸癌的進展中起重要作用,評估原髮大腸癌組織中PSMA7的錶達水平對判斷是否繼髮肝轉移有一定指導意義.
목적 탐토단백매체아기PSMA7재대장암중적표체급의의.방법 응용면역조화법검측수술절제적62례원발대장암조직、34례전이림파결화13례간전이조직중PSMA7적표체.병분석PSMA7적표체여림상병리지간적관계.결과 PSMA7재정상대장조직중균위음성혹약양성,이재38.7%(24/62)원발대장암조직、52.9%(18/34)전이림파결화100%(13/13)간전이조직중고표체,차원발대장암조직적PSMA7고표체여간전이밀절상관(P=0.028).PSMA7고표체조적환자생존솔명현저우PSMA7저표체조(P=0.0008).재생존솔다인소분석중,PSMA7표체위영향환자예후적독립인소(P=0.004,상대위험도5, 057,95%가신구간위1.682-15.201).결론 PSMA7가능재대장암적진전중기중요작용,평고원발대장암조직중PSMA7적표체수평대판단시부계발간전이유일정지도의의.
Objective To investigate the correlation between the proteasome subunit PSMA7 expression in colorectal cancer and its role in liver metastasis. Methods To identify the PSMA7 protein expression in 62 primary site eoiorectal cancers, 34 lymph node metastatic sites and 13 liver metastatic sites by immunohistochemistry and clarify the correlation of its expression with the clinicopathologieal parameters.Results High expression of PSMA7 was detected in 38.7% (24/62) of primary site eolorectal cancer,52.9% (18/34) of lymph node metastatic sites and 100% (13/13) liver metastatic sites but not in the normal colorectal tissue. High expression of PSMA7 was significantly correlated with liver metastasis (P =0.028). The survival rate was significantly lower in patients with high expression of PSMA7 than in those with low expression of PSMA7 ( P = 0. 0008 ). As well, in multivariate analysis, PSMA7 expression demonstrated to be an independent prognostic factor (P =0. 004, relative risk 5. 057; 95% confidence interval, 1. 682-15.201). Conclusion PSMA7 may play an important role in the colorectal cancer progressian. Evaluation of PSMA7 expression in primary eolorectal cancer at the time of surgery might be a valuable test in defining patients with a high risk of developing liver metastasis.
