中华传染病杂志
中華傳染病雜誌
중화전염병잡지
CHINESE JOURNAL OF INFECTIOUS DISEASES
2011年
10期
611-614
,共4页
吴仲文%章益民%盛吉芳%李兰娟
吳仲文%章益民%盛吉芳%李蘭娟
오중문%장익민%성길방%리란연
肝炎,乙型,慢性%核苷类似物%聚乙二醇干扰素α-2a%肝炎表面抗原,乙型
肝炎,乙型,慢性%覈苷類似物%聚乙二醇榦擾素α-2a%肝炎錶麵抗原,乙型
간염,을형,만성%핵감유사물%취을이순간우소α-2a%간염표면항원,을형
Hepatitis B,chronic%Nucleos(t)ide analogs%Peg IFNα-2a%HBsAg
目的 观察HBeAg阳性慢性乙型肝炎(CHB)患者在核苷(酸)类似物抗病毒治疗基础上序贯聚乙二醇干扰素α-2a(PEG IFNα-2a)治疗48周血清HBsAg的变化.方法 6例HBeAg阳性CHB患者中,3例采用核苷(酸)类似物序贯PEG IFNα-2a治疗48周,3例维持原核苷(酸)类似物治疗方案,每12周采用实时PCR定量检测HBV DNA,采用时间分辨免疫荧光分析法检测HBsAg、抗-HBs、HBeAg、抗-HBe及抗-HBc.结果 核苷(酸)类似物序贯PEG lFNα-2a治疗48周后,3例序贯治疗患者血清HBsAg均消失,而维持原核苷(酸)类似物治疗患者血清HBsAg效价为100～320 IU/mL.结论 对核苷(酸)类似物治疗产生较好应答反应且伴有血清HBsAg效价明显下降的HBeAg阳性CHB患者,在核苷(酸)类似物抗病毒治疗基础上序贯PEG IFNα-2a治疗48周能有效促进血清HBsAg下降,并出现血清HBsAg消失的现象.
目的 觀察HBeAg暘性慢性乙型肝炎(CHB)患者在覈苷(痠)類似物抗病毒治療基礎上序貫聚乙二醇榦擾素α-2a(PEG IFNα-2a)治療48週血清HBsAg的變化.方法 6例HBeAg暘性CHB患者中,3例採用覈苷(痠)類似物序貫PEG IFNα-2a治療48週,3例維持原覈苷(痠)類似物治療方案,每12週採用實時PCR定量檢測HBV DNA,採用時間分辨免疫熒光分析法檢測HBsAg、抗-HBs、HBeAg、抗-HBe及抗-HBc.結果 覈苷(痠)類似物序貫PEG lFNα-2a治療48週後,3例序貫治療患者血清HBsAg均消失,而維持原覈苷(痠)類似物治療患者血清HBsAg效價為100～320 IU/mL.結論 對覈苷(痠)類似物治療產生較好應答反應且伴有血清HBsAg效價明顯下降的HBeAg暘性CHB患者,在覈苷(痠)類似物抗病毒治療基礎上序貫PEG IFNα-2a治療48週能有效促進血清HBsAg下降,併齣現血清HBsAg消失的現象.
목적 관찰HBeAg양성만성을형간염(CHB)환자재핵감(산)유사물항병독치료기출상서관취을이순간우소α-2a(PEG IFNα-2a)치료48주혈청HBsAg적변화.방법 6례HBeAg양성CHB환자중,3례채용핵감(산)유사물서관PEG IFNα-2a치료48주,3례유지원핵감(산)유사물치료방안,매12주채용실시PCR정량검측HBV DNA,채용시간분변면역형광분석법검측HBsAg、항-HBs、HBeAg、항-HBe급항-HBc.결과 핵감(산)유사물서관PEG lFNα-2a치료48주후,3례서관치료환자혈청HBsAg균소실,이유지원핵감(산)유사물치료환자혈청HBsAg효개위100～320 IU/mL.결론 대핵감(산)유사물치료산생교호응답반응차반유혈청HBsAg효개명현하강적HBeAg양성CHB환자,재핵감(산)유사물항병독치료기출상서관PEG IFNα-2a치료48주능유효촉진혈청HBsAg하강,병출현혈청HBsAg소실적현상.
Objective To investigate the changes of hepatitis B sarfaceantigen (HBsAg) titer in hepatitis B e antigen (HBeAg) positive chronic hepatitis B (CHB) patients treated with nucleos(t)ide analogs and pegylated interferon alfa-2a (PEG IFNα-2a) sequential therapy.Methods Among 6 HBeAg positive CHB patients,3 patients were treated with nucleos(t)ide analogs followed by PEG IFNα-2a for 48 weeks,3 patients were treated with nucleos(t)ide analog monotherapy.The serum HBsAg,anti-HBs,HBeAg,anti-HBe and anti-HBc were detected using the time-resolved immunofluorometric assay and serum hepatitis B virus (HBV) DNA levels were determined by Taqman polymerase chain reaction (PCR) every 12 weeks.Results HBsAg loss were achieved in three patients after 48-week nucleos(t)ide analogs and PEG IFNα-2a sequential therapy.However,the HBsAg titers of another 3 patients varied from 100 IU/mL to 320 IU/mL.Conclusion In HBeAg positive CHB patients who obtain virologic response accompanied with HBsAg titer decreasing dramatically by nucleos(t) ide analog treatment,PEG IFNα-2a sequential treatment can increase HBsAg clearance rate.
