CAJ | 학술논문

目的探讨高频电磁场(25～30MHz)对女性生殖内分泌的毒性作用.方法调查福州市区180名接触高频电磁场1年以上的鞋业女工及福州市区日用品超市349名身体健康的女工的月经状况与妊娠结局情况;随机抽取接触组与对照组女工(处排卵期)各30人,静脉采血,制备血清,并采用放射免疫法测定雌激素(E2)、孕激素(P4)、卵泡刺激素(FSH)和黄体生成素(LH)水平.结果高频电磁场接触1组和接触2组女工月经紊乱发生率(分别为33.8%、26.8%)明显高于对照组(12.0%),差异有统计学意义(P＜0.01);接触1组女工月经经量异常发生率(16.9%)明显高于对照组(8.0%),差异有统计学意义(P＜0.05).接触1组和接触2组P4水平[分别为(2.10±1.57)、(2.39±1.35)mg/L]明显低于对照组[(3.80±2.67)mg/L],差异有统计学意义(P＜0.01).接触组E2、FSH和LH水平与对照组比较,差异无统计学意义(P＜0.05).结论一定强度高频电磁场可导致女工月经紊乱及月经经量异常发生率增加,对孕激素具有抑制作用.
목적 탐토고빈전자장(25～30MHz)대녀성생식내분비적독성작용.방법 조사복주시구180명접촉고빈전자장1년이상적혜업녀공급복주시구일용품초시349명신체건강적녀공적월경상황여임신결국정황;수궤추취접촉조여대조조녀공(처배란기)각30인,정맥채혈,제비혈청,병채용방사면역법측정자격소(E2)、잉격소(P4)、란포자격소(FSH)화황체생성소(LH)수평.결과 고빈전자장접촉1조화접촉2조녀공월경문란발생솔(분별위33.8%、26.8%)명현고우대조조(12.0%),차이유통계학의의(P＜0.01);접촉1조녀공월경경량이상발생솔(16.9%)명현고우대조조(8.0%),차이유통계학의의(P＜0.05).접촉1조화접촉2조P4수평[분별위(2.10±1.57)、(2.39±1.35)mg/L]명현저우대조조[(3.80±2.67)mg/L],차이유통계학의의(P＜0.01).접촉조E2、FSH화LH수평여대조조비교,차이무통계학의의(P＜0.05).결론 일정강도고빈전자장가도치녀공월경문란급월경경량이상발생솔증가,대잉격소구유억제작용.
Objective To analyze the toxicity of high-frequency electromagnetic field (HF-EMF) on the reproductive and endocrine functions of female workers. Methods 180 female workers exposed to HFEMF for more than one year were selected as the exposure group, and 349 female workers in the marketplace were selected as the control group. Their menstrual status and pregnancy outcomes were evaluated with historical cohort study. Meanwhile, the serum levels of reproductive hormones including follicle stimulation hormone (FSH), luteinizing hormone (LH), estradiol (E2) and progesterone (P4) from 30 workers respectively in the exposure group and the control group selected randomly (in periovulatory period) were detected with the radio immunoassays. Results With the increase of residue of HF-EMF, the incidence of menstrual disorder was increased (33.8% and 26.8% in the exposure group compared with 12.0% in the control group) (P＜0.01) and the incidence of menorrhagia in the exposure I group (16.9%) was significantly higher than that in the control group (8.0%) (P＜0.01). However, serum P4 was significantly lower in the exposure group [(2.10±1.57) and (2.39±1.35)mg/L]than in the control group [(3.80±2.67)mg/L](P＜0.01). There was no significant difference in serum E2, LH and FSH between the exposure and the control groups. Conclusion Increase of the incidence of menstrual disorder as well as that of menorrhagia, and decrease of levels of some reproductive hormones are closely associated with HF-EMF (25～30MHz).