中华核医学杂志
中華覈醫學雜誌
중화핵의학잡지
CHINESE JOURNAL OF NUCLEAR MEDICINE
2010年
6期
383-386
,共4页
韩大力%钟小军%于金明%穆殿斌%付正%张百江%张利民%张为迪%刘曙光%赵书强%王晓慧%袁芳%王红爱
韓大力%鐘小軍%于金明%穆殿斌%付正%張百江%張利民%張為迪%劉曙光%趙書彊%王曉慧%袁芳%王紅愛
한대력%종소군%우금명%목전빈%부정%장백강%장이민%장위적%류서광%조서강%왕효혜%원방%왕홍애
食管肿瘤%肿瘤转移%淋巴结%体层摄影术,发射型计算机%体层摄影术,X线计算机%胸苷%脱氧葡萄糖
食管腫瘤%腫瘤轉移%淋巴結%體層攝影術,髮射型計算機%體層攝影術,X線計算機%胸苷%脫氧葡萄糖
식관종류%종류전이%림파결%체층섭영술,발사형계산궤%체층섭영술,X선계산궤%흉감%탈양포도당
Esophageal neoplasms%Neoplasm metastasis%Lymph nodes%Tomography,emission-computed%Tomography,X-ray computed%Thymidine%Deoxyglucose
目的 评价18F-脱氧胸苷(FLT)PET/CT对未经治疗的胸段食管癌淋巴结分期诊断的价值,并与18F-脱氧葡萄糖(FDG)PET/CT进行比较.方法 选择22例拟行手术治疗的胸段食管癌患者,术前行双显像剂PET/CT检查及淋巴结分期诊断,术后以病理学诊断为"金标准",比较18F-FLT和18F-FDG PET/CT对胸段食管癌淋巴结分期的灵敏度、特异性、准确性、阳性预测值和阴性预测值.应用SPSS 13.0软件进行x2检验.结果 患者均行食管癌切除和淋巴结清扫术,病理检查结果显示16例患者存在淋巴结转移,N0期7例,N1期15例,M1a期6例(其中1例为N0M1a,另外5例为N1M1a),全组均无M1b期.共检出424枚淋巴结,其中47枚为转移淋巴结.18F-FDG PET/CT诊断呈假阳性的淋巴结14枚,而18F-FLT诊断呈假阳性的淋巴结为3枚;18F-FDG假阴性的淋巴结8枚,18F-FLT假阴性的淋巴结12枚.18F-FLT PET/CT的诊断灵敏度、特异性、准确性、阴性预测值和阳性预测值分别为74.47%(35/47)、99.20%(374/377)、96.46%(409/424)、96.89%(374/386)和92.11%(35/38),18F-FDG分别为82.98%(39/47)、96.29%(363/377)、94.81%(402/424)、97.84%(363/371)和73.58%(39/53);两者比较的x2值分别为0.572,6.018,1.017,0.348,3.852,P值分别＞0.05,＜0.05、＞0.05、＞0.05和＞0.05.结论 18F-FLT对食管癌区域淋巴结的诊断灵敏度与18F-FDG显像接近,特异性高于18F-FDG,但仍存在一定的局限性.
目的 評價18F-脫氧胸苷(FLT)PET/CT對未經治療的胸段食管癌淋巴結分期診斷的價值,併與18F-脫氧葡萄糖(FDG)PET/CT進行比較.方法 選擇22例擬行手術治療的胸段食管癌患者,術前行雙顯像劑PET/CT檢查及淋巴結分期診斷,術後以病理學診斷為"金標準",比較18F-FLT和18F-FDG PET/CT對胸段食管癌淋巴結分期的靈敏度、特異性、準確性、暘性預測值和陰性預測值.應用SPSS 13.0軟件進行x2檢驗.結果 患者均行食管癌切除和淋巴結清掃術,病理檢查結果顯示16例患者存在淋巴結轉移,N0期7例,N1期15例,M1a期6例(其中1例為N0M1a,另外5例為N1M1a),全組均無M1b期.共檢齣424枚淋巴結,其中47枚為轉移淋巴結.18F-FDG PET/CT診斷呈假暘性的淋巴結14枚,而18F-FLT診斷呈假暘性的淋巴結為3枚;18F-FDG假陰性的淋巴結8枚,18F-FLT假陰性的淋巴結12枚.18F-FLT PET/CT的診斷靈敏度、特異性、準確性、陰性預測值和暘性預測值分彆為74.47%(35/47)、99.20%(374/377)、96.46%(409/424)、96.89%(374/386)和92.11%(35/38),18F-FDG分彆為82.98%(39/47)、96.29%(363/377)、94.81%(402/424)、97.84%(363/371)和73.58%(39/53);兩者比較的x2值分彆為0.572,6.018,1.017,0.348,3.852,P值分彆＞0.05,＜0.05、＞0.05、＞0.05和＞0.05.結論 18F-FLT對食管癌區域淋巴結的診斷靈敏度與18F-FDG顯像接近,特異性高于18F-FDG,但仍存在一定的跼限性.
목적 평개18F-탈양흉감(FLT)PET/CT대미경치료적흉단식관암림파결분기진단적개치,병여18F-탈양포도당(FDG)PET/CT진행비교.방법 선택22례의행수술치료적흉단식관암환자,술전행쌍현상제PET/CT검사급림파결분기진단,술후이병이학진단위"금표준",비교18F-FLT화18F-FDG PET/CT대흉단식관암림파결분기적령민도、특이성、준학성、양성예측치화음성예측치.응용SPSS 13.0연건진행x2검험.결과 환자균행식관암절제화림파결청소술,병리검사결과현시16례환자존재림파결전이,N0기7례,N1기15례,M1a기6례(기중1례위N0M1a,령외5례위N1M1a),전조균무M1b기.공검출424매림파결,기중47매위전이림파결.18F-FDG PET/CT진단정가양성적림파결14매,이18F-FLT진단정가양성적림파결위3매;18F-FDG가음성적림파결8매,18F-FLT가음성적림파결12매.18F-FLT PET/CT적진단령민도、특이성、준학성、음성예측치화양성예측치분별위74.47%(35/47)、99.20%(374/377)、96.46%(409/424)、96.89%(374/386)화92.11%(35/38),18F-FDG분별위82.98%(39/47)、96.29%(363/377)、94.81%(402/424)、97.84%(363/371)화73.58%(39/53);량자비교적x2치분별위0.572,6.018,1.017,0.348,3.852,P치분별＞0.05,＜0.05、＞0.05、＞0.05화＞0.05.결론 18F-FLT대식관암구역림파결적진단령민도여18F-FDG현상접근,특이성고우18F-FDG,단잉존재일정적국한성.
Objective To compare the diagnostic value 18F-fluorothymidine (FLT) and 18F-fluorodeoxyglucose (FDG) PET/CT in detecting lymph node metastases of untreated thoracic esophageal carcinoma. Methods Twenty-two patients with thoracic esophageal squamous cell carcinoma underwent both 18F-FLT and 18F-FDG PET/CT before surgery. The imaging results of the two modalities in detecting regional lymph node metastases were compared prospectively with the pathologic findings. The X2-test was used with SPS S 13.0. Results All patients underwent esophagectomy and lymphadenectomy. The metastatic lymph nodes were found in 16 patients, from which 47 of 424 excised nodes were positive by pathologic examination. False positive results were 14 while false negative 8 on 18F-FDG PET/CT. In contrast, false positive results were only 3 but false negative were 12 on 18 F-FLT PET/CT. The sensitivity, specificity, accuracy,negative predictive value, and positive predictive value were 74.47% ( 35/47 ), 99.20% ( 374/377 ),96.46% (409/424), 96.89% ( 374/386 ) and 92.11% ( 35/38 ) respectively for 18 F-FLT PET/CT, whereas the corresponding values were 82.98% (39/47), 96.29% (363/377), 94.81% (402/424), 97.84%(363/371 ) and 73.58% (39/53) respectively for 18 F-FDG PET/CT (X2 = 0.572, 6.018, 1.017, 0.348,3.852, P＞0. 05, ＜0.05, ＞0.05, ＞0.05 and ＞0.05). Conclusions Compared with 18F-FDG PET/CT, 18F-FLT PET/CT may be less sensitive but more specific for the detection of lymph node metastases of thoracic esophageal carcinoma.
