中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
2011年
10期
796-798
,共3页
胃肿瘤%流式细胞术%淋巴细胞亚群%抗原,CD19%生存率
胃腫瘤%流式細胞術%淋巴細胞亞群%抗原,CD19%生存率
위종류%류식세포술%림파세포아군%항원,CD19%생존솔
Stomach neoplasms%Flow cytometry%Lymphocyte subsets%Antigens,CD19%Survival rate
目的 探讨胃癌患者外周血淋巴细胞亚群表达与生存率的关系.方法 用流式细胞仪检测833例胃癌首诊患者外周血的淋巴细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+、CD19+、CD25+、CD44+及NK+细胞,并根据96名健康对照者的平均检测值分为高表达组和低表达组,比较各亚群高表达组与低表达组患者的生存率.结果 与健康对照者相比,胃癌患者CD3+、CD8+低表达,而CD4+、CD19+、CD25+、CD4+/CD8+、CD44+、NK+高表达(P＜0.05).CD19+高表达与低表达者分别为444例和389例,3年生存率为36.4％和18.5％,差异有统计学意义(P＜0.05)；而其他7种淋巴细胞亚群表达水平则与患者生存率无关(均P＞0.05).结论 与健康人群相比,胃癌患者外周血淋巴细胞亚群发生显著变化,其中CD19+高表达患者具有明显的生存优势.
目的 探討胃癌患者外週血淋巴細胞亞群錶達與生存率的關繫.方法 用流式細胞儀檢測833例胃癌首診患者外週血的淋巴細胞亞群CD3+、CD4+、CD8+、CD4+/CD8+、CD19+、CD25+、CD44+及NK+細胞,併根據96名健康對照者的平均檢測值分為高錶達組和低錶達組,比較各亞群高錶達組與低錶達組患者的生存率.結果 與健康對照者相比,胃癌患者CD3+、CD8+低錶達,而CD4+、CD19+、CD25+、CD4+/CD8+、CD44+、NK+高錶達(P＜0.05).CD19+高錶達與低錶達者分彆為444例和389例,3年生存率為36.4％和18.5％,差異有統計學意義(P＜0.05)；而其他7種淋巴細胞亞群錶達水平則與患者生存率無關(均P＞0.05).結論 與健康人群相比,胃癌患者外週血淋巴細胞亞群髮生顯著變化,其中CD19+高錶達患者具有明顯的生存優勢.
목적 탐토위암환자외주혈림파세포아군표체여생존솔적관계.방법 용류식세포의검측833례위암수진환자외주혈적림파세포아군CD3+、CD4+、CD8+、CD4+/CD8+、CD19+、CD25+、CD44+급NK+세포,병근거96명건강대조자적평균검측치분위고표체조화저표체조,비교각아군고표체조여저표체조환자적생존솔.결과 여건강대조자상비,위암환자CD3+、CD8+저표체,이CD4+、CD19+、CD25+、CD4+/CD8+、CD44+、NK+고표체(P＜0.05).CD19+고표체여저표체자분별위444례화389례,3년생존솔위36.4％화18.5％,차이유통계학의의(P＜0.05)；이기타7충림파세포아군표체수평칙여환자생존솔무관(균P＞0.05).결론 여건강인군상비,위암환자외주혈림파세포아군발생현저변화,기중CD19+고표체환자구유명현적생존우세.
Objective To study the change of lymphocyte subgroups in the peripheral blood of patients with gastric carcinoma and its association with survival.Methods Flow cytometry was used to examine the subgroups of lymphocytes ( CD3+,CD4+,CD8+,CD4+/CD8+,CD 19+,CD25+,CD44+ and NK cells) in the peripheral blood of 833 gastric carcinoma patients prior to any therapy.Patients were divided into the high expression group and lower expression group according to the average test values of 96 healthy control subjects.Survival rate was compared between the two groups.Results Compared with control group,the levels of CD3+ and CD8+ T cell in patients were significantly lower,while the levels of CD4+,CD19+,CD25+,CD4VCD8+,CD44+,and NK+ cells were significantly.The differences were statistically significant (P＜0.05).Three-year survival rates of gastric cancer patients with high CD19+ expression (n=444) and cases with low CD19+ expression (n=389) were 36.4％ and 18.5％,respectively (P＜0.05).The expressions of other seven types of lymphocytes were not associated with survival rates (all P＞0.05).Conclusions Significant changes in lymphocyte subgroups exist in the peripheral blood of patients with gastric carcinoma.Patients with high CD19+ expression have better survival.
