CAJ | 학술논문

目的研究精氨洛芬对骨关节炎(OA)和类风湿关节炎(RA)的疗效及安全性,并与布洛芬进行比较. 方法 171例OA和RA患者随机分成精氨洛芬组(400 mg,每日3次)和布洛芬组(400 mg,每日3次)治疗,疗程为4周.对两药治疗前后关节疼痛、压痛、肿胀指数和研究者、患者的总体疗效评价进行比较. 结果精氨洛芬和布洛芬在治疗4周后平均关节疼痛、压痛和肿胀指数的变化差异无统计学意义,但精氨洛芬组起效时间较布洛芬早,差异有统计学意义;两组的不良事件发生率差异无统计学意义,两组皆无严重不良事件发生. 结论精氨洛芬与布洛芬对膝OA和RA的止痛作用和副作用一致,精氨洛芬起效更快.
목적 연구정안락분대골관절염(OA)화류풍습관절염(RA)적료효급안전성,병여포락분진행비교. 방법 171례OA화RA환자수궤분성정안락분조(400 mg,매일3차)화포락분조(400 mg,매일3차)치료,료정위4주.대량약치료전후관절동통、압통、종창지수화연구자、환자적총체료효평개진행비교. 결과 정안락분화포락분재치료4주후평균관절동통、압통화종창지수적변화차이무통계학의의,단정안락분조기효시간교포락분조,차이유통계학의의;량조적불량사건발생솔차이무통계학의의,량조개무엄중불량사건발생. 결론 정안락분여포락분대슬OA화RA적지통작용화부작용일치,정안락분기효경쾌.
Objective To compare the clinical efficacy of ibuprofen arginate,a new nonsteroidal antiinflammatory drug,with that of ibuprofen,in patients with rheumatoid arthritis or knee osteoarthritis and to evaluate the safety and tolerability of ibuprofen argihate.Methods This is a muhicenter,random,open,active comparator-controlled,parallel clinical trail in which 171 patients with rheumatoid arthritis or knee osteoarthritis were enrolled.Patients were randomized to 2 groups:400 mg of ibuprofen arginate three times daily and 400 mg of ibuprofen three times daily respectively.Clinical efficacy and safety were evaluated after 4-week treatment.Results Ibuprofen arginate,at dosages of 400 mg three times daily,had shown significant efficacy in relieving pain,tenderness and swelling of joints and there was no significant difference when compared to that of ibuprofen.There was no difference in clinical adverse effects between the two groups and no serious adverse effects were repofled.But ibuprofen arginate could initiate effectiveness more rapidly than ibuprofen in both rheumatoid arthritisand osteoarthritis patients.Conclusion Ibuprofen arginate has the same clinical efficacy and safety profiles as itmprofen in treating rheumatoid arthritis and osteoarthritis.However,its onset is more rapid than ibuprofen.