中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
8期
972-974
,共3页
Lewis血型%自身抗体%抗体筛检%输血
Lewis血型%自身抗體%抗體篩檢%輸血
Lewis혈형%자신항체%항체사검%수혈
Lewis blood system%Autoantibodies%Antibody screening%Blood transfusion
目的 研究Lewis血型系统抗原、抗体血型血清学鉴定的方法,对含有抗-Lea、抗-Leb抗体和自身抗体患者的输血效果进行评估.方法 采用全自动血型/配血系统按照血型血清学检测方法对患者进行1ewis血型鉴定,由血型室筛选与患者相合的血液给予患者输注,同时严密观察患者输血情况,评估其输注效果.结果 患者ABO血型为A型,Rh血型系统表型为CCDEe,Lewis血型系统表型为Le(a+b－)；血清中不仅含有抗-Lea和抗-Leb抗体,同时存在自身抗体.经治疗,对患者输注经血型室筛选且配血相合的红细胞、同型血浆和机采血小板,逐步达到预期输血效果,患者血红蛋白水平相对稳定.结论 通过对患者进行抗体筛检及Lewis血型抗体鉴定,筛选出与患者配血相合的血液成分进行输注观察；抗-Lea、抗-Leb抗体和自身抗体阳性患者输注血液成分后临床效果极差,经过治疗后可使输血效果逐步好转,血红蛋白稳定在一定水平上.
目的 研究Lewis血型繫統抗原、抗體血型血清學鑒定的方法,對含有抗-Lea、抗-Leb抗體和自身抗體患者的輸血效果進行評估.方法 採用全自動血型/配血繫統按照血型血清學檢測方法對患者進行1ewis血型鑒定,由血型室篩選與患者相閤的血液給予患者輸註,同時嚴密觀察患者輸血情況,評估其輸註效果.結果 患者ABO血型為A型,Rh血型繫統錶型為CCDEe,Lewis血型繫統錶型為Le(a+b－)；血清中不僅含有抗-Lea和抗-Leb抗體,同時存在自身抗體.經治療,對患者輸註經血型室篩選且配血相閤的紅細胞、同型血漿和機採血小闆,逐步達到預期輸血效果,患者血紅蛋白水平相對穩定.結論 通過對患者進行抗體篩檢及Lewis血型抗體鑒定,篩選齣與患者配血相閤的血液成分進行輸註觀察；抗-Lea、抗-Leb抗體和自身抗體暘性患者輸註血液成分後臨床效果極差,經過治療後可使輸血效果逐步好轉,血紅蛋白穩定在一定水平上.
목적 연구Lewis혈형계통항원、항체혈형혈청학감정적방법,대함유항-Lea、항-Leb항체화자신항체환자적수혈효과진행평고.방법 채용전자동혈형/배혈계통안조혈형혈청학검측방법대환자진행1ewis혈형감정,유혈형실사선여환자상합적혈액급여환자수주,동시엄밀관찰환자수혈정황,평고기수주효과.결과 환자ABO혈형위A형,Rh혈형계통표형위CCDEe,Lewis혈형계통표형위Le(a+b－)；혈청중불부함유항-Lea화항-Leb항체,동시존재자신항체.경치료,대환자수주경혈형실사선차배혈상합적홍세포、동형혈장화궤채혈소판,축보체도예기수혈효과,환자혈홍단백수평상대은정.결론 통과대환자진행항체사검급Lewis혈형항체감정,사선출여환자배혈상합적혈액성분진행수주관찰；항-Lea、항-Leb항체화자신항체양성환자수주혈액성분후림상효과겁차,경과치료후가사수혈효과축보호전,혈홍단백은정재일정수평상.
Objective To study the serological identification method of the Lewis blood system antigens and antibodies and to evaluate the transfusion effectiveness of patients with anti-Lea and anti-Leb antibodies combined with autoantibodies.Methods According to serological theories,we identified the Lewis blood type of the patient using automatic blood/blood compatibility test system.Then we selected the compatible blood and observed the condition of the patient during and after the infusion to evaluate the effectiveness of transfusion.Results The patient was type A blood of the ABO system.The phenotype of Rh system was CCDEe and the phenotype of Lewis system was Le(a + b-).There were not only anti-Lea and anti-Leb antibodies but also autoantibodies in the patient's serum.Infusion of the compatible blood turned out successful.Conclusions Through the antibody screening and antibody identification of the Lewis blood group,screening and infusion of the compatible blood components for patients are observed.The effectiveness of transfusion therapy in refractory anemia patient is poor.However,after appropriate treatments it would be improved.
