CAJ | 학술논문

采用猪一犬肾移植建立超急性排斥反应模型,以研究此时的血液流变学变化.分别在移植前、移植肾超急性排斥发生时和排斥肾切除后10～15分钟检测外周血的血液流变学参数变化.结果异种肾移植发生超急性排斥时,血小板聚集显著增高,移植肾切除后血中的血小板数和纤维蛋白原明显下降,血小板聚集也恢复原有水平.提示血小板、纤维蛋白原参与了异种移植超急性排斥反应的发生过程,而血小板聚集可能是诊断异种移植超急性排斥反应一个有价值的指标.
채용저일견신이식건립초급성배척반응모형,이연구차시적혈액류변학변화.분별재이식전、이식신초급성배척발생시화배척신절제후10～15분종검측외주혈적혈액류변학삼수변화.결과이충신이식발생초급성배척시,혈소판취집현저증고,이식신절제후혈중적혈소판수화섬유단백원명현하강,혈소판취집야회복원유수평.제시혈소판、섬유단백원삼여료이충이식초급성배척반응적발생과정,이혈소판취집가능시진단이충이식초급성배척반응일개유개치적지표.
Ten kidney xenograftings were performed in dog to pig combination.Hemorrheological parameters were detected respectively before transplantation,at the hyperacute rejection and at 10～15 minutes after the removal of the rejected kidneys.The results showed that platelet aggregation increased significantly in hyperacute rejection.Platelet and fibrinogen decreased signifieantly and the platelet aggregation recovered at 10～15 minutes after rejected kidneys were removed.It is indicated that the platelet and fibrinogen participate in the hyperacute xenograft rejection,and that platelet aggregation may provide a voluable and sensitive assay for hyperacute xenograft rejection.