CAJ | 학술논문

采用CCl_4灌胃造成小鼠急性肝损伤模型,将大豆多肽分为高、中、低剂量组,分别为3、1.8、0.6g/kg·d喂饲小鼠30d,观察其对血清GPT、GOT和ALP及肝脏TG、TC、MDA和GSH的影响.实验结果表明:成功建立小鼠急性肝损伤模型,与模型组比较,大豆多肽可显著降低血清中GOT、GPT和ALP活性和肝脏TG、TC和MDA含量,提高肝脏中GSH含量,以高剂量组效果最佳,呈明显的剂量依赖性.大豆多肽对CCl_4引起的小鼠急性肝损伤具有保护作用.
채용CCl_4관위조성소서급성간손상모형,장대두다태분위고、중、저제량조,분별위3、1.8、0.6g/kg·d위사소서30d,관찰기대혈청GPT、GOT화ALP급간장TG、TC、MDA화GSH적영향.실험결과표명:성공건립소서급성간손상모형,여모형조비교,대두다태가현저강저혈청중GOT、GPT화ALP활성화간장TG、TC화MDA함량,제고간장중GSH함량,이고제량조효과최가,정명현적제량의뢰성.대두다태대CCl_4인기적소서급성간손상구유보호작용.
Mice with acute liver injury were modeled through CCl_4 induction and orally administered with soybean polypeptides at doses of 3, 1.8 and 0.6g/kg·d for 30 d, respectively. Effects of soybean polypeptides on glutamic-oxaloacetic transminase (GOT), glutarnic-pyruvic transminase (GPT) and alkaline phosphataes (ALP) in serum and triglyceride (TG), total cholesterol (TC), malondialdehye (MDA) and glutathione peroxidase (GSH) levels in liver were investigated. Results indicated that CCl_4-induced mice model with liver injury was successfully established. Soybean polypeptides significantly decreased the levels of GOT, GPT and AST in serum and TG, TC and MDA in liver, and obviously increased the level of GSH in liver in a dose-dependent manner. Therefore, soybean polypeptides have an excellent protective capability against acute liver injury in mice induced by COl_4.