CAJ | 학술논문

目的探讨药物性肝损害的临床特点及治疗方法.方法对2000-2008年我院收治的药物性肝损害206例患者的临床资料进行回顾性分析.结果引起肝损害的药物种类繁多,以抗生素(包括抗结核药物)为最多,占40.3%(83/206),其次为抗肿瘤药,占15.5%(32/206).临床以肝细胞型多见,占49.5%(102/206),胆汁淤积型占29.6%(61/206),混合型占20.9%(43/206).主要临床表现有纳差、乏力、黄疸、上腹部不适、皮疹、发热.实验室检查丙氨酸氨基转移酶升高206例(100.0%);碱性磷酸酶升高108例(52.4%);总胆红素升高54例(26.2%).临床治愈165例,好转32例,自动出院7例,死亡2例.结论引起药物性肝损害的药物种类很多,应及早发现及时治疗.
목적 탐토약물성간손해적림상특점급치료방법.방법 대2000-2008년아원수치적약물성간손해206례환자적림상자료진행회고성분석.결과 인기간손해적약물충류번다,이항생소(포괄항결핵약물)위최다,점40.3%(83/206),기차위항종류약,점15.5%(32/206).림상이간세포형다견,점49.5%(102/206),담즙어적형점29.6%(61/206),혼합형점20.9%(43/206).주요림상표현유납차、핍력、황달、상복부불괄、피진、발열.실험실검사병안산안기전이매승고206례(100.0%);감성린산매승고108례(52.4%);총담홍소승고54례(26.2%).림상치유165례,호전32례,자동출원7례,사망2례.결론 인기약물성간손해적약물충류흔다,응급조발현급시치료.
Objective To analyse the clinical characteristics and the treatment of drug-induced liver injury.Methods Two hundred and six patients with drug-induced liver injury admitted to our hospital from 2000 to 2008 were reviewed retrospectively.Results A variety of drugs were involved in causing liver disease.The common offending agents were antimicrobial agents(40.3%,83/206),and antineoplastic(15.5%,32/206);49.5%(102/206) was classified as hepatocellular type,29.6%(61/206) as cholestatic type,and 20.9%(43/206) as mixed type.The main clinical manifestations were fatigue,jaundice,anorexia,epigastrium uncomfortable,rash,fever.The laboratory tests of liver functions showed increased levels of ALT (100.0%),ALP (52.4%,108/206) and TD(26.2%,54/206).165 patients recovered,32 patients improved,and 2 patients died.Conclusions A variety of drugs can induce liver disease.