CAJ | 학술논문

2009年3月至2010年10月Ⅱ～Ⅲ级慢性阻塞性肺疾病急性加重期住院患者25例,健康对照组20例,测定所有入选者痰液中炎症细胞水平、痰上清液中自细胞介素-8(IL-8)和嗜酸粒细胞趋化因子(eotaxin)的含量,测定肺功能第1秒用力呼气容积占预计值百分比和第1秒用力呼气容积/用力肺活量.患者痰液中中性粒细胞和嗜酸性粒细胞比例均高于健康对照组(P<0.01),IL-8和eotaxin含量均高于健康对照组(P<0.01),且IL-8与中性粒细胞比例及eotaxin含量与嗜酸性粒细胞比例分别呈正相关(P<0.01),IL-8和eotaxin含量分别与第1秒用力呼气容积占预计值百分比呈负相关(P<0.01).说明IL-8和eotaxin可能在慢性阻塞性肺疾病气道炎症和气道不可逆性阻塞发生发展过程中起着重要作用.
2009년3월지2010년10월Ⅱ～Ⅲ급만성조새성폐질병급성가중기주원환자25례,건강대조조20례,측정소유입선자담액중염증세포수평、담상청액중자세포개소-8(IL-8)화기산립세포추화인자(eotaxin)적함량,측정폐공능제1초용력호기용적점예계치백분비화제1초용력호기용적/용력폐활량.환자담액중중성립세포화기산성립세포비례균고우건강대조조(P<0.01),IL-8화eotaxin함량균고우건강대조조(P<0.01),차IL-8여중성립세포비례급eotaxin함량여기산성립세포비례분별정정상관(P<0.01),IL-8화eotaxin함량분별여제1초용력호기용적점예계치백분비정부상관(P<0.01).설명IL-8화eotaxin가능재만성조새성폐질병기도염증화기도불가역성조새발생발전과정중기착중요작용.
The clinical data of 25 patients with acute exacerbations of chronic obstruction pulmonary disease (AECOPD) admitted from March 2009 to October 2010 were analyzed. The sputum samples were collected and the levels of inflammatory cell, interleukin-8 (IL-8) and eotaxin in sputum were determined. The lung function was measured. Twenty healthy subjects served as controls. The counts of neutrophils and eosinophils, and the levels of IL-8 and eotaxin in sputum of AECOPD were higher than those of health subjects. There was a positive correlation between the levels of IL-8 and the counts of neutrophils (P < 0. 01), and between the levels of eotaxin and the counts of eosinophils in sputum ( P < 0.01). The levels of IL-8 and eotaxin were negatively correlated with the lung function (FEV1% ).