CAJ | 학술논문

目的探讨E-钙黏(E-cadherin,E-cad)蛋白表达与大肠癌的发生、发展及预后的关系.方法利用免疫组化SP法,检测101例大肠癌原发灶、10例腺瘤及20例正常大肠黏膜组织中E-cad蛋白表达.结果 E-cad的低表达与肿瘤分期、分化,有无淋巴结转移及远处转移相关(P<0.05);与肿瘤组织类型、浸润深度、部位、大小以及性别和年龄无相关性(P>0.05);E-cad阳性表达组与阴性组之间比较,生存期无显著性差异(P>0.05).结论大肠癌组织中E-cad低表达与大肠癌发生、发展、侵袭转移有关.
목적 탐토E-개점(E-cadherin,E-cad)단백표체여대장암적발생、발전급예후적관계.방법 이용면역조화SP법,검측101례대장암원발조、10례선류급20례정상대장점막조직중E-cad단백표체.결과 E-cad적저표체여종류분기、분화,유무림파결전이급원처전이상관(P<0.05);여종류조직류형、침윤심도、부위、대소이급성별화년령무상관성(P>0.05);E-cad양성표체조여음성조지간비교,생존기무현저성차이(P>0.05).결론 대장암조직중E-cad저표체여대장암발생、발전、침습전이유관.
Objective To investigate the correlation between the expression of E-cadherin(E-cad)protein and invasion,metastasis and prognosis in colorectal cancinoma(CRC).Methods The expression of E-cad protein were measured by immunohistochemistry in 101 specimens of CRC,10 specimens of colorectal adenoma and 20 specimens of normal tissues.Results The reduced-expression of E-cad protein was associated with Dukes stages and degree of differentiation,lymph nodes and distant organs metastasis(P<0.05);there was no correlation with types of neoplasms,depth of infiltration,location,size,gender and age(P>0.05).The difference of survival periods between positive and negative groups on E-cad protein was not signficant(P>0.05).Conclusion The reduced-expression of E-cad protein is closely associated with invasion and metastasis in colorectal cancer.