CAJ | 학술논문

目的总结我院治疗儿童肝母细胞瘤的经验.方法回顾性分析2000年6月至2007年1月经病理证实的27例肝母细胞瘤患儿的临床及随访资料.结果本组按国际儿童肿瘤协会(SIOP) PRETEXT分期:Ⅰ期3例,Ⅱ期10例,Ⅲ期1 1例,Ⅳ期3例.本组采用手术联合化疗的综合治疗措施,其中Ⅰ期手术3例,Ⅱ期手术24例.治疗后获得完全缓解22例,获得部分缓解2例,疾病进展2例,于术后化疗中死亡1例.至随访结束,20例无病生存,4例死于肿瘤复发,2例死于进展.27例的5年生存率为74.1％.结论联合术前化疗后肿瘤可完全切除的肝母细胞瘤患儿可长期生存,而化疗后手术仍无法切除或治疗后复发的患儿的预后较差.
목적 총결아원치료인동간모세포류적경험.방법 회고성분석2000년6월지2007년1월경병리증실적27례간모세포류환인적림상급수방자료.결과 본조안국제인동종류협회(SIOP) PRETEXT분기:Ⅰ기3례,Ⅱ기10례,Ⅲ기1 1례,Ⅳ기3례.본조채용수술연합화료적종합치료조시,기중Ⅰ기수술3례,Ⅱ기수술24례.치료후획득완전완해22례,획득부분완해2례,질병진전2례,우술후화료중사망1례.지수방결속,20례무병생존,4례사우종류복발,2례사우진전.27례적5년생존솔위74.1％.결론 연합술전화료후종류가완전절제적간모세포류환인가장기생존,이화료후수술잉무법절제혹치료후복발적환인적예후교차.
Objective To summarize the therapeutic efficacy evaluation for children with hepatoblastoma.Methods Between June 2000 and January 2007,total 27 patients with hepatoblastoma underwent treatment in out center and histological report confirmed clinical diagnosis.In this study the clinical data and follow-up outcome were retrospectively analyzed.Results The SlOP PRETEXT staging criteria was used in this study,among all patients 3 cases were diagnosed as PRETEXT Ⅰ,10 cases as PRETEXT Ⅱ,11 cases as PRETEXT Ⅲ,and 3 cases as PRETEXT Ⅳ respectively.All patients were treated with multidisciplinary approaches involving surgery combined with chemotherapy.3 patients underwent one-stage operation without preoperative chemotherapy,while 24 patients underwent preoperative chemotherapy before surgery.Afterwards,22 patients of all achieved complete remission,2 reached partial remission,2 patients were still in progression,and 1 patient died during the period of postoperative chemotherapy.By the end of follow up,20 patients had a disease-free-survival,while 4 patients died due to recurrences and 2 died from progression.The overall 5 year survival rate was 74.1 ％.Conclusions Patients with complete resection after chemotherapy survive well,while for those without completion resection after chemotherapy or with recurrence,will encounter a poor prognosis.