CAJ | 학술논문

凋亡抑制蛋白Livin是凋亡抑制因子(IAP)家族的新成员,在多种肿瘤细胞中高表达,参与抑制细胞凋亡,与肿瘤发生、发展及预后密切相关,是一种具有潜在价值的肿瘤标志物,可作为肿瘤早期诊断和治疗的新分子靶点.本文就Livin基因分子结构、组织表达、生物学功能及在肿瘤治疗中的应用等研究进展作一综述.
조망억제단백Livin시조망억제인자(IAP)가족적신성원,재다충종류세포중고표체,삼여억제세포조망,여종류발생、발전급예후밀절상관,시일충구유잠재개치적종류표지물,가작위종류조기진단화치료적신분자파점.본문취Livin기인분자결구、조직표체、생물학공능급재종류치료중적응용등연구진전작일종술.
Livin is a new member of the inhibitors of apoptosis protein(IAP) gene family. It is highly expressed in most human tumors, involved in inhibiting cell apoptosis, and closely related with tumor occurrence, development and prognosis. So Livin could be a new target for tumorous early diagnosis and cancer therapy. This paper summarizes the Livin gene molecular structure, tissue expression, biological function,and its application in cancer treatment.