中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2003年
4期
265-267
,共3页
2型糖尿病%高半胱氨酸%血管疾病
2型糖尿病%高半胱氨痠%血管疾病
2형당뇨병%고반광안산%혈관질병
Diabetes mellitus, type 2%Homocysteine% Vascular disease
目的探讨2型糖尿病患者(T2DM)血浆总同型半胱氨酸(stHcy)水平、影响因素及其与大血管病变的关系. 方法对191例T2DM患者及23名正常对照人群采用高压液相层析方法测定stHcy、B型超声检查测定颈动脉内膜中层厚度(IMT),并测定各临床、生化参数. 结果 (1)T2DM患者组stHcy总体水平与正常对照组比较差异无显著意义(P=0.31).其中stHcy≥15.1 μmol/L组的年龄、高血压病程、血清肌酐、尿酸、尿白蛋白排泄率、IMT增厚发生率较stHcy<15.1 μmol/L组高,肾小球滤过率、糖化血红蛋白较stHcy<15.1 μmol/L组低(P<0.001～0.05).(2)IMT增厚组stHcy和高stHcy百分率较IMT正常组和正常对照组明显增高(P<0.05～0.001).多元逐步线性回归分析显示,stHcy与IMT增厚呈独立相关.(OR=1.365,P<0.001,95%可信区间1.139～1.637). 结论 T2DM患者stHcy受病程不同阶段的多种因素影响.stHcy增高是大血管病变的独立危险因素.
目的探討2型糖尿病患者(T2DM)血漿總同型半胱氨痠(stHcy)水平、影響因素及其與大血管病變的關繫. 方法對191例T2DM患者及23名正常對照人群採用高壓液相層析方法測定stHcy、B型超聲檢查測定頸動脈內膜中層厚度(IMT),併測定各臨床、生化參數. 結果 (1)T2DM患者組stHcy總體水平與正常對照組比較差異無顯著意義(P=0.31).其中stHcy≥15.1 μmol/L組的年齡、高血壓病程、血清肌酐、尿痠、尿白蛋白排洩率、IMT增厚髮生率較stHcy<15.1 μmol/L組高,腎小毬濾過率、糖化血紅蛋白較stHcy<15.1 μmol/L組低(P<0.001～0.05).(2)IMT增厚組stHcy和高stHcy百分率較IMT正常組和正常對照組明顯增高(P<0.05～0.001).多元逐步線性迴歸分析顯示,stHcy與IMT增厚呈獨立相關.(OR=1.365,P<0.001,95%可信區間1.139～1.637). 結論 T2DM患者stHcy受病程不同階段的多種因素影響.stHcy增高是大血管病變的獨立危險因素.
목적탐토2형당뇨병환자(T2DM)혈장총동형반광안산(stHcy)수평、영향인소급기여대혈관병변적관계. 방법대191례T2DM환자급23명정상대조인군채용고압액상층석방법측정stHcy、B형초성검사측정경동맥내막중층후도(IMT),병측정각림상、생화삼수. 결과 (1)T2DM환자조stHcy총체수평여정상대조조비교차이무현저의의(P=0.31).기중stHcy≥15.1 μmol/L조적년령、고혈압병정、혈청기항、뇨산、뇨백단백배설솔、IMT증후발생솔교stHcy<15.1 μmol/L조고,신소구려과솔、당화혈홍단백교stHcy<15.1 μmol/L조저(P<0.001～0.05).(2)IMT증후조stHcy화고stHcy백분솔교IMT정상조화정상대조조명현증고(P<0.05～0.001).다원축보선성회귀분석현시,stHcy여IMT증후정독립상관.(OR=1.365,P<0.001,95%가신구간1.139～1.637). 결론 T2DM환자stHcy수병정불동계단적다충인소영향.stHcy증고시대혈관병변적독립위험인소.
Objective To investigate the plasma total homocystein (stHcy) level, its affecting factors and its relationship with macrovascular diseases in type 2 diabetecs. Methods The stHcy concentration was determined by HPLC method. The intimal medial thikeness(IMT) of common carotid artery was measured by ultrasonography. The clinical and biochemical data were analysed. Results (1)The stHcy level in group of type 2 diabetics was not different from controls ( P >0.5) The age, duration of high blood pressure, serum creatinine, serum uric acid, urine albumin excretive rate,the percentage of patients with IMT 0.8 mm were higher in group of stHcy 15.1 μmol/L. The glumerular filtration rate, glucosyleted hemoglubulin A1c were lower than those in group of stHcy<15.1 μmol/L significantly( P <0.05-0.001) (2)The stHtcy level and the percentage of high stHcy in group of thickened IMT was higher than those in normal IMT group and controls( P <0.05～0.001). Multiple linear regresson analysis showed that the stHcy correlated with IMT independently Conclusions The stHcy in diabetic patients was affected by different factors, The high level of stHcy is independent risk factor for macrovascular disease in type 2 DM.
