CAJ | 학술논문

支气管哮喘(简称哮喘)是一种常见的慢性气道炎症性疾病,氧化应激在其发生发展机制中具有重要的作用.机体受到的氧化应激刺激有内源性和外源性两种途径,通过产生的氧自由基对细胞和分子造成多种形式的损伤.哮喘患者体内氧化水平升高,抗氧化机制降低.研究发现,在哮喘患者或动物模型体内使用一些具有抗氧化作用的物质进行干预可有效预防或拮抗氧化应激损伤,对于哮喘的防治具有重要的意义.
지기관효천(간칭효천)시일충상견적만성기도염증성질병,양화응격재기발생발전궤제중구유중요적작용.궤체수도적양화응격자격유내원성화외원성량충도경,통과산생적양자유기대세포화분자조성다충형식적손상.효천환자체내양화수평승고,항양화궤제강저.연구발현,재효천환자혹동물모형체내사용일사구유항양화작용적물질진행간예가유효예방혹길항양화응격손상,대우효천적방치구유중요적의의.
Bronchial asthma is a common chronic airway inflammatic disease. Oxidative stress plays an important role in the pathogenesis and development of asthma.The stimuli of oxidative stress can be originated endogenously or exogenously,both produce various injuries on molecules and cells through the induction of radical oxygen species.The level of oxidative stress is often elevated in asthmatic patients,accompanied by the impaired anti-oxidant capacity. Numerous studies using anti-oxidant therapies or interventions on both human patients and animal models have elicited some positive results.It is of great importance in prophylaxis and treatment of asthma to efficiently prevent or attenuate oxidative stress-induced damage.