CAJ | 학술논문

目的探讨胃结肠癌患者血清胸苷激酶1(Thymidine kinase 1,TK1)的分布情况和诊断价值.方法免疫印迹增强化学发光法检测70例胃结肠癌患者(研究组)、48例健康体检者(对照组)的血清TK1值,分析分布形态,计算基于参考值的阳性率,比较集中趋势,ROC曲线分析诊断价值.结果研究组与对照组的偏度系数分别为4.975、0.836,研究组的阳性率高于对照组(37.14％ vs 4.17％,P＜0.01),研究组的中位数大于对照组(1.56 vs 0.91,P＜0.01),ROC曲线下面积为0.7987,临界值为2.025 pmol/L时,阳性似然比为最大值17.83,灵敏度、特异度分别为37.14％、97.92％.结论胃结肠癌患者的TK1值呈正偏分布,可能预示癌细胞和宿主细胞的增殖状态差异,其阳性率和中位数均高于正常对照组,参考值为2.025 pmol/L的诊断价值较高.
목적 탐토위결장암환자혈청흉감격매1(Thymidine kinase 1,TK1)적분포정황화진단개치.방법 면역인적증강화학발광법검측70례위결장암환자(연구조)、48례건강체검자(대조조)적혈청TK1치,분석분포형태,계산기우삼고치적양성솔,비교집중추세,ROC곡선분석진단개치.결과 연구조여대조조적편도계수분별위4.975、0.836,연구조적양성솔고우대조조(37.14％ vs 4.17％,P＜0.01),연구조적중위수대우대조조(1.56 vs 0.91,P＜0.01),ROC곡선하면적위0.7987,림계치위2.025 pmol/L시,양성사연비위최대치17.83,령민도、특이도분별위37.14％、97.92％.결론 위결장암환자적TK1치정정편분포,가능예시암세포화숙주세포적증식상태차이,기양성솔화중위수균고우정상대조조,삼고치위2.025 pmol/L적진단개치교고.
Objective To explore the distribution charateristics and evaluate the diagnostic value of serum thymidine kinase 1(TK1) in the gastric and colonic cancer patients.Methods 70 cases of gastric and colonic cancer patients(observation group)、48 cases of healthy people(control group) underwent serum TK1 detection using an ECL dot blot assay,TK1's statistical distribution、positive rate and central tendency were analyzed and compared between two groups,its clinical diagnostic value was evaluated using receiver operating characteristic (ROC) curve.Results The coefficients of skewness were 4.975、0.836 in observation group and control group respectively,the positve rate in observation group was significantly higher than that in control group(37.14％ vs 4.17％,P＜ 0.01),the TK1 median in observation group was also significantly higher than that in control group(1.56 vs 0.91,P＜ 0.01),ROC analysis showed that the area under curve (AUC) was 0.7987.When the cutoff value was 2.025 pmol/L,the positive likelihood ratio was the biggest(17.83),then the sensitivity and specificity were 37.14％、97.92％ respectively.Conclusions TK1 values in gastric and colonic cancer patients are not normal distribution,its outliers may imply the proliferation difference of both cancer and non-cancer cells,its positive rate and median are significantly higher than those of healthy people,its diagnostic value is best when cutoff value is 2.025pmol/L.