CAJ | 학술논문

目的探讨抑郁症患者对情感刺激的行为学反应模式及其相关的杏仁核时程反应过程.方法 12例首次发病、未经治疗的抑郁症患者(抑郁症组)和13名健康个体(健康对照组)对观看正性、中性和负性情绪图片的愉悦度等评分;并在被动注视任务下行功能磁共振成像,采用感兴趣区分析方法,比较两组杏仁核在不同情绪图片任务组块间的血氧水平依赖(BOLD)信号时间反应特征.结果 (1)抑郁症组情绪图片愉悦度评分[正性:(6.6 ±0.2)分;中性:(4.7 ±0.1)分]低于健康对照组[分别为(7.7 ±0.2)分和(5.1 ±0.1)分],负性情绪图片评分[(3.4 ±0.3)分]高于健康对照组[(2.2 ±0.2)分;P<0.01].(2)对正性情绪图片任务,两组间右侧杏仁核存在"组×时间"交互作用(P=0.002);抑郁症组杏仁核BOLD信号变化率为(0.02±0.09)%,激活时间后移至Block 2.对负性情绪图片任务,两组间左侧杏仁核有"组×时间"交互作用(P=0.008),右侧杏仁核存在组主效应(P=0.007)和时间主效应(P=0.016),抑郁症组BOLD信号变化率低于(-0.06 ±0.14)%.结论杏仁核是抑郁症患者丧失愉悦体验和情绪低落的神经基础之一.
목적 탐토억욱증환자대정감자격적행위학반응모식급기상관적행인핵시정반응과정.방법 12례수차발병、미경치료적억욱증환자(억욱증조)화13명건강개체(건강대조조)대관간정성、중성화부성정서도편적유열도등평분;병재피동주시임무하행공능자공진성상,채용감흥취구분석방법,비교량조행인핵재불동정서도편임무조괴간적혈양수평의뢰(BOLD)신호시간반응특정.결과 (1)억욱증조정서도편유열도평분[정성:(6.6 ±0.2)분;중성:(4.7 ±0.1)분]저우건강대조조[분별위(7.7 ±0.2)분화(5.1 ±0.1)분],부성정서도편평분[(3.4 ±0.3)분]고우건강대조조[(2.2 ±0.2)분;P<0.01].(2)대정성정서도편임무,량조간우측행인핵존재"조×시간"교호작용(P=0.002);억욱증조행인핵BOLD신호변화솔위(0.02±0.09)%,격활시간후이지Block 2.대부성정서도편임무,량조간좌측행인핵유"조×시간"교호작용(P=0.008),우측행인핵존재조주효응(P=0.007)화시간주효응(P=0.016),억욱증조BOLD신호변화솔저우(-0.06 ±0.14)%.결론 행인핵시억욱증환자상실유열체험화정서저락적신경기출지일.
Objective To explore the behavioral and related amygdaiar temporal response to emotional pictures in individuals with major depressive disorder(MDD).Methods Functional magnetic resonance imaging(fMRI)was adopted to examine the neural substrates of emotional pictures processing in 12 first-episode unmedicated MDD subjects(MDD)and 13 healthy controls(HC).Analyses were focused on the temporal dynamics of the blood-oxygen level dependant(BOLD)signal change in the amygdala across blocks of positive,neutral and negative emotional pictures.The crude score to emotional pictures was also recorded.Results(1)The crude score wag(6.6 ±0.2)to positive pictures and(4.7 ±0.1)to neutral pictures in depressed subjects,lower than that in HC(P＜0.01),and(3.4 ±0.3)to negativc pictures in depressed subjects,which was higher than that in HC(2.2±0.2,P＜0.01).(2)The bilateral amygdala showed attenuated and delayed response to the positive pictures.in which the right amygdala showed"group×time"interaction effect to positive pictures(P=0.002).For the negative pictures,there was"group×time"interaction effect in the left amygdala(P=0.008)and group main effect in the right amygdaia(P=0.007),with the attenuated BOLD signal change in MDD group.Conclusions It suggests that amygdala is one of the key neural substrates to the character of the depressed mood or loss of interest in individuals with MDD.Depressed subiects show the attenuated and blunted behavioral and amygdala response to emotional stimuli,which support the hypothesis of the unspecially blunted emotional response in major depressive disorder.