CAJ | 학술논문

目的探讨肺鳞癌组织中淋巴管分布和存在状态及可能的原因.方法肺鳞癌组40例,肺炎性假瘤组10例.用LYVE-1/CD34免疫组化双染色法区分淋巴管和血管并观察淋巴管内皮透明质酸受体-1(LYVE-1)蛋白表达的情况.结果1.肺鳞癌组织周边部淋巴管密度远大于内部和炎性假瘤组织.2.网状淋巴管肺鳞癌组织周边部远大于肺鳞癌组织内部及炎性假瘤组织.塌陷淋巴管肺鳞癌组织周边部密度小于肺鳞癌组织内部而大于炎性假瘤组织,塌陷淋巴管肺鳞癌组织内部密度远大于炎性假瘤组织;3.在肺鳞癌组织周边部:单腔淋巴管密度远大于塌陷淋巴管密度和网状淋巴管密度,塌陷淋巴管密度小于网状淋巴管密度.在肺鳞癌组织内部:单腔淋巴管密度小于塌陷淋巴管密度而大于网状淋巴管密度,塌陷淋巴管密度大于网状淋巴管密度.在炎性假瘤组织:单腔淋巴管密度远大于塌陷淋巴管密度和网状淋巴管密度.结论肺鳞癌组织淋巴管生成主要在周边部,肺鳞癌组织内部淋巴管塌陷明显增多导致的淋巴管无功能状态可能主要是由于高间质压引起的.
목적탐토폐린암조직중림파관분포화존재상태급가능적원인.방법폐린암조40례,폐염성가류조10례.용LYVE-1/CD34면역조화쌍염색법구분림파관화혈관병관찰림파관내피투명질산수체-1(LYVE-1)단백표체적정황.결과1.폐린암조직주변부림파관밀도원대우내부화염성가류조직.2.망상림파관폐린암조직주변부원대우폐린암조직내부급염성가류조직.탑함림파관폐린암조직주변부밀도소우폐린암조직내부이대우염성가류조직,탑함림파관폐린암조직내부밀도원대우염성가류조직;3.재폐린암조직주변부:단강림파관밀도원대우탑함림파관밀도화망상림파관밀도,탑함림파관밀도소우망상림파관밀도.재폐린암조직내부:단강림파관밀도소우탑함림파관밀도이대우망상림파관밀도,탑함림파관밀도대우망상림파관밀도.재염성가류조직:단강림파관밀도원대우탑함림파관밀도화망상림파관밀도.결론폐린암조직림파관생성주요재주변부,폐린암조직내부림파관탑함명현증다도치적림파관무공능상태가능주요시유우고간질압인기적.
Objective: To investigate the distribution and existing statues in pulmonary squamous cell carcinoma tissue and its possible causes. Methods: Double immunohistochemical staining for LYVE-1/CD34for 40 cases of pulmonary squamocellular carcinoma and 10 cases of pulmonary inflammatory pseudotumor were performed to distinguish lymphoducts and blood vessels, and to observe the lymphatic vessel endothelial HA receptor-1 (LYVE-1) manifestation. Results: 1. The density of lymphatic vessels was elevated in the perimeter of the pulmonary squamocellular carcinoma tissue relative to the interior of that and the pulmonary inflammatory pseudotumor normal tissue. 2. The reticular lymphoducts in the perimeter of the pulmonary squamocellular carcinoma tissue was higher than that in the interior and the pulmonary inflammatory pseudotumor. The density of collapsed lymphoducts in the perimeter of the pulmonary squamocellular carcinoma tissue was lower than that in the interior and higher than that in the pulmonary inflammatory pseudotumor. The density of collapsed lymphoducts in the interior of the pulmonary squamocellular carcinoma tissue was much higher than that in the pulmonary inflammatory pseudotumor. 3. The density of single lumen lymphoducts was much higher than that of collapsed and reticular lymphoducts and the density of collapsed lymphoducts was lower than that of reticular lymphoducts in the perimeter of the pulmonary squamocellular carcinoma tissue.The density of single lumen lymphoducts was lower than that of reticular lymphoducts and higher than that of reticular lymphoducts in the interior of the pulmonary squamocellular carcinoma tissue. The density of collapsed lymphoducts was highe r than that of reticular lymphoducts in the interior of the pulmonary squamocellular carcinoma tissue. The density of single lumen lymphoducts was much higher than that of collapsed and reticular lymphoducts in the pulmonary inflammatory pseudotumor. Conclusions: The production of lymphoducts is mainly in the perimeter of the pulmonary squamocellular carcinoma tissue. The clearly accelerated number of collapsed lymphoducts in the interior of the pulmonary squamocellular carcinoma tissue which lead to the dysfunction of lymphoducts mainly due to the high interstitial pressure.