CAJ | 학술논문

目的探讨慢性肾衰竭患者甲状腺激素水平的变化以及临床意义. 方法住院治疗的慢性肾衰竭(尿毒症期)患者79例,分为慢性肾衰竭非透析组30例;血液透析组30例;腹膜透析组19例,用电化学发光法分别检测血清FT3、FT4、sTSH水平,另选同期健康体检者作为对照.结果慢性肾衰竭非透析组、血液透析组及腹膜透析组血清FT3显著低于正常对照(2.84±0.76,3.54±0.60,3.24±1.05 vs 4.40±0.91 pmol/L,P<0.01),FT4低于正常对照,但差异无统计学意义(16.77±12.31,12.81±2.89,16.51±4.51 vs 17.99±1.86pmol/L,P>0.05),sTSH高于正常对照,但差异无统计学意义(3.79±3.19,3.56±3.35,9.15±14.46 vs 2.62±1.35μIU/ml,P>0.05).慢性肾衰竭非透析组与透析组,腹膜透析组与血液透析组之间甲状腺激素各项指标变化差异无统计学意义.结论慢性肾衰竭患者常伴有甲状腺激素水平异常,表现为低T3、低T4综合征,透析不能改善慢性肾衰竭患者甲状腺激素水平异常.
목적 탐토만성신쇠갈환자갑상선격소수평적변화이급림상의의. 방법주원치료적만성신쇠갈(뇨독증기)환자79례,분위만성신쇠갈비투석조30례;혈액투석조30례;복막투석조19례,용전화학발광법분별검측혈청FT3、FT4、sTSH수평,령선동기건강체검자작위대조.결과 만성신쇠갈비투석조、혈액투석조급복막투석조혈청FT3현저저우정상대조(2.84±0.76,3.54±0.60,3.24±1.05 vs 4.40±0.91 pmol/L,P<0.01),FT4저우정상대조,단차이무통계학의의(16.77±12.31,12.81±2.89,16.51±4.51 vs 17.99±1.86pmol/L,P>0.05),sTSH고우정상대조,단차이무통계학의의(3.79±3.19,3.56±3.35,9.15±14.46 vs 2.62±1.35μIU/ml,P>0.05).만성신쇠갈비투석조여투석조,복막투석조여혈액투석조지간갑상선격소각항지표변화차이무통계학의의.결론 만성신쇠갈환자상반유갑상선격소수평이상,표현위저T3、저T4종합정,투석불능개선만성신쇠갈환자갑상선격소수평이상.
Objective To investigate the changes of serum thyroid hormone in patients with chronic renal failure (CRF) and who un-derwent dialysis. Methods Serum hee-T3 (FT3), free-T4 (FT4) and thyretropin (s-TSH) concentrations were measured by electrochemilumines-cence in 79 patients with CRF, and 30 normal-control subjects. Results Serum levels of FT3 were significantly lower in patients with CRF than that in normal controls (P<0.01),FF4 and sTSH contents were not different compared with normal controls (P>0.05). While levels of serum thyroid hormone among the three CRF groups including dialysis and non-dialysis were not significant. Conclusion Low T3 or low T4 syndrome is very common in patients with CRF. Dialysis cann't change this state.