化学研究
化學研究
화학연구
CHEMICAL RESEARCHES
2013年
4期
403-407
,共5页
选择性脱保护%叔丁基二甲基硅%Na3 PO4?12H2 O
選擇性脫保護%叔丁基二甲基硅%Na3 PO4?12H2 O
선택성탈보호%숙정기이갑기규%Na3 PO4?12H2 O
selective deprotection%t-butyldimethylsilyl%Na3 PO4?12H2 O
报道了以磷酸盐为催化剂选择性脱去芳香性叔丁基二甲基硅醚的方法．以DMF为溶剂，室温下在0．5质量分数的Na3 PO4?12H2 O催化下，能顺利地脱去芳香性叔丁基二甲基硅醚得到相应的酚类化合物，而不影响其他的保护基和官能团．
報道瞭以燐痠鹽為催化劑選擇性脫去芳香性叔丁基二甲基硅醚的方法．以DMF為溶劑，室溫下在0．5質量分數的Na3 PO4?12H2 O催化下，能順利地脫去芳香性叔丁基二甲基硅醚得到相應的酚類化閤物，而不影響其他的保護基和官能糰．
보도료이린산염위최화제선택성탈거방향성숙정기이갑기규미적방법．이DMF위용제，실온하재0．5질량분수적Na3 PO4?12H2 O최화하，능순리지탈거방향성숙정기이갑기규미득도상응적분류화합물，이불영향기타적보호기화관능단．
A facile protocol to the chemoselective deprotection of aryl t-butyldimethylsilyl (TB-DMS) ethers using Na3 PO4?12H2 O as promoter is described .From aryl TBDMS ethers to the corresponding phenols ,the TBDMS group could be cleaved in the presence of 0 .5 equivalent of Na3 PO4?12H2 O in DMF at room temperature with good to excellent yields in the presence of other common protecting and functional groups .This is ,to our knowledge ,the first report on chemoselective deprotection of aryl TBDMS ethers using phosphates .
